公开(公告)号：EP0950059B1

公开(公告)日：2004-08-04

申请号：EP97946016.9

申请日：1997-12-18

申请人： PFIZER INC.

发明人： BURGESS, Laurence, Edward ,  RIZZI, James, Patrick

IPC分类号： C07D493/08 ,  A61K31/34

CPC分类号： C07D493/08 ,  C07D307/00

公开(公告)号：EP0950059A1

公开(公告)日：1999-10-20

申请号：EP97946016.0

申请日：1997-12-18

申请人： PFIZER INC.

发明人： BURGESS, Laurence, Edward ,  RIZZI, James, Patrick

IPC分类号： A61K31 ,  A61K45 ,  A61P1 ,  A61P19 ,  A61P31 ,  A61P35 ,  C07D307 ,  C07D493

CPC分类号： C07D493/08 ,  C07D307/00

摘要： A compound of formula (I), wherein n, X, Y and Ar are as defined herein, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.