公开(公告)号：EP0056681A3

公开(公告)日：1983-07-20

申请号：EP82300018

申请日：1982-01-05

申请人： PFIZER INC.

发明人： Aguiar, Armando Joseph ,  Rasadi, Bijan

IPC分类号： A61K09/08 ,  A61K31/47

CPC分类号： A61K9/1075 ,  A61K31/47 ,  Y10S514/973

摘要： A pharmaceutical composition comprising an aqueous micellar solution of, as the active ingredient, (a) levonantradol or (b) N-methyllevonantradol, or a pharmaceutically acceptable acid addition salt of (a) or (b), and (c) at least a critical micelle concentration of a nonionic amphiphile. Also covered are pharmaceutically acceptable lyophile compositions prepared by the lyophilization of the aqueous micellar solutions. Levonantradol and N-methyllevonantradol are analgetic and anti-emetic agents.

公开(公告)号：EP0056681A2

公开(公告)日：1982-07-28

申请号：EP82300018.7

申请日：1982-01-05

申请人： PFIZER INC.

发明人： Aguiar, Armando Joseph ,  Rasadi, Bijan

IPC分类号： A61K9/08 ,  A61K31/47

CPC分类号： A61K9/1075 ,  A61K31/47 ,  Y10S514/973

摘要： A pharmaceutical composition comprising an aqueous micellar solution of, as the active ingredient, (a) levonantradol or (b) N-methyllevonantradol, or a pharmaceutically acceptable acid addition salt of (a) or (b), and (c) at least a critical micelle concentration of a nonionic amphiphile. Also covered are pharmaceutically acceptable lyophile compositions prepared by the lyophilization of the aqueous micellar solutions.
Levonantradol and N-methyllevonantradol are analgetic and anti-emetic agents.

摘要翻译： （a）或（b）作为活性成分的（a）左炔诺酮醇或（b）N-甲基莱酮甾醇或其药学上可接受的酸加成盐的水性胶束溶液，和（c）至少一种 非离子两亲物的临界胶束浓度。 还涵盖了通过冻干胶束水溶液制备的药学上可接受的冻干组合物。 Levonantradol和N-methyllevonantradol是止痛药和止吐药。