专利检索 ap:("PFIZER PHARMACEUTICALS INC." OR "PFIZER INC.") AND inv:"KOJIMA, N.-Pfizer Pharm. Inc., Nagoya Plant Res." 第 1 页

1.

发明公开
MACROCYCLIC LACTONE COMPOUNDS AND THEIR PRODUCTION PROCESS 失效
标题翻译： MACROCYKLISCHE内酯及其制备方法

公开(公告)号：EP0854874A1

公开(公告)日：1998-07-29

申请号：EP95932876.0

申请日：1995-10-13

申请人： PFIZER PHARMACEUTICALS INC. , PFIZER INC.

发明人： NISHIDA, H.-Pfizer Pharm. Inc., Nagoya Plant Res. , YAMAUCHI, Y.-Pfizer Phar. Inc.,NagoyaPlant Res. , INAGAKI, T.-Pfizer Phar. Inc., Nagoya Plant Res. , KOJIMA, Y.-Pfizer Phar. Inc.,Nagoya Plant Res. , KOJIMA, N.-Pfizer Pharm. Inc., Nagoya Plant Res.

IPC分类号： C07D , B65B57 , A61K31 , A61K35 , A61P31 , A61P35 , A61P37 , B65G43 , C07D209 , C07D273 , C07D311 , C07D498 , C07H19 , C12P1 , C12P17 , G01B11 , G05B19 , G05D3 , C12R1

CPC分类号： C07D498/18 , C12P17/188

摘要： This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocyclic lactone compound from the fermentation broth. The compounds produced by this process include a compound of formula (I). The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.

2.

发明授权
MACROCYCLIC LACTONE COMPOUNDS AND THEIR PRODUCTION PROCESS 失效
标题翻译： MACROCYKLISCHE内酯及其制备方法

公开(公告)号：EP0854874B1

公开(公告)日：2003-05-02

申请号：EP95932876.6

申请日：1995-10-13

申请人： PFIZER INC.

发明人： NISHIDA, H.-Pfizer Pharm. Inc., Nagoya Plant Res. , YAMAUCHI, Y.-Pfizer Phar. Inc.,NagoyaPlant Res. , INAGAKI, T.-Pfizer Phar. Inc., Nagoya Plant Res. , KOJIMA, Y.-Pfizer Phar. Inc.,Nagoya Plant Res. , KOJIMA, N.-Pfizer Pharm. Inc., Nagoya Plant Res.

IPC分类号： C07D498/18 , C12P17/18 , A61K31/445 , C12P1/06

CPC分类号： C07D498/18 , C12P17/188

摘要： This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocyclic lactone compound from the fermentation broth. The compounds produced by this process include a compound of formula (I). The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.