公开(公告)号：EP1442022A4

公开(公告)日：2005-05-04

申请号：EP02802875

申请日：2002-11-07

申请人： PHARMACIA CORP

发明人： PHILLION DENNIS P ,  CROWLEY KATHLEEN S ,  BASHKIN JAMES K ,  SCHWEITZER BARBARA A ,  BURNETTE BARRY L ,  WOODARD SCOTT S

IPC分类号： C12N15/09 ,  A61K31/4025 ,  A61K31/4178 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07D207/30 ,  C07D403/14 ,  C07K14/575 ,  C12N5/02 ,  C12N15/63

CPC分类号： C12N15/635 ,  C07K14/575

摘要： Processes and compositions are provided for regulating COX2 gene expression in a cell. The process includes selecting a polyamide composition comprising N-methyl pyrrole (Py) and N-methyl imidazole (Im) to provide specific binding to DNA at a COX2 gene target site in a cell. The polyamide is then combined with the cell containing the COX2 gene, wherein the polyamide binds to the COX2 gene promoter target site and regulates transcription of the COX2 gene.