公开(公告)号：EP1224215A1

公开(公告)日：2002-07-24

申请号：EP00975093.6

申请日：2000-10-24

申请人： PHARMACIA DIAGNOSTICS AB ,  Valenta, Rudolf

发明人： VALENTA, Rudolf ,  VRTALA, Susanne ,  STUMMVOLL, Sabine ,  GRÖNLUND, Hans ,  GROTE, Monika ,  VANGELISTA, Luca ,  PASTORE, Annalisa,c/o Molecular Structure Div ,  SPERR, Wolfgang, R. ,  VALENT, Peter ,  KRAFT, Dietrich

IPC分类号： C07K14/415 ,  A61K39/36 ,  A61P37/08

CPC分类号： A61K39/36 ,  A61K38/00 ,  A61K39/00 ,  C07K14/415

摘要： The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising: (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the complete sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis.

公开(公告)号：EP1224215B1

公开(公告)日：2005-08-17

申请号：EP00975093.6

申请日：2000-10-24

申请人： Pharmacia Diagnostics AB ,  Valenta, Rudolf

发明人： VALENTA, Rudolf ,  VRTALA, Susanne ,  STUMMVOLL, Sabine ,  GRÖNLUND, Hans ,  GROTE, Monika ,  VANGELISTA, Luca ,  PASTORE, Annalisa, c/o Molecular Structure Div ,  SPERR, Wolfgang, R. ,  VALENT, Peter ,  KRAFT, Dietrich

IPC分类号： C07K14/415 ,  A61K39/36 ,  A61P37/08

CPC分类号： A61K39/36 ,  A61K38/00 ,  A61K39/00 ,  C07K14/415

摘要： The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising: (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the complete sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis.

公开(公告)号：EP1224215B2

公开(公告)日：2010-10-06

申请号：EP00975093.6

申请日：2000-10-24

申请人： Phadia AB ,  Valenta, Rudolf

发明人： VALENTA, Rudolf ,  VRTALA, Susanne ,  STUMMVOLL, Sabine ,  GRÖNLUND, Hans ,  GROTE, Monika ,  VANGELISTA, Luca ,  PASTORE, Annalisa, c/o Molecular Structure Div ,  SPERR, Wolfgang, R. ,  VALENT, Peter ,  KRAFT, Dietrich

IPC分类号： C07K14/415 ,  A61K39/36 ,  A61P37/08

CPC分类号： A61K39/36 ,  A61K38/00 ,  A61K39/00 ,  C07K14/415