公开(公告)号：EP1224215B2

公开(公告)日：2010-10-06

申请号：EP00975093.6

申请日：2000-10-24

申请人： Phadia AB ,  Valenta, Rudolf

发明人： VALENTA, Rudolf ,  VRTALA, Susanne ,  STUMMVOLL, Sabine ,  GRÖNLUND, Hans ,  GROTE, Monika ,  VANGELISTA, Luca ,  PASTORE, Annalisa, c/o Molecular Structure Div ,  SPERR, Wolfgang, R. ,  VALENT, Peter ,  KRAFT, Dietrich

IPC分类号： C07K14/415 ,  A61K39/36 ,  A61P37/08

CPC分类号： A61K39/36 ,  A61K38/00 ,  A61K39/00 ,  C07K14/415

公开(公告)号：EP1224215A1

公开(公告)日：2002-07-24

申请号：EP00975093.6

申请日：2000-10-24

申请人： PHARMACIA DIAGNOSTICS AB ,  Valenta, Rudolf

发明人： VALENTA, Rudolf ,  VRTALA, Susanne ,  STUMMVOLL, Sabine ,  GRÖNLUND, Hans ,  GROTE, Monika ,  VANGELISTA, Luca ,  PASTORE, Annalisa,c/o Molecular Structure Div ,  SPERR, Wolfgang, R. ,  VALENT, Peter ,  KRAFT, Dietrich

IPC分类号： C07K14/415 ,  A61K39/36 ,  A61P37/08

CPC分类号： A61K39/36 ,  A61K38/00 ,  A61K39/00 ,  C07K14/415

摘要： The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising: (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the complete sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis.

公开(公告)号：EP1224215B1

公开(公告)日：2005-08-17

申请号：EP00975093.6

申请日：2000-10-24

申请人： Pharmacia Diagnostics AB ,  Valenta, Rudolf

发明人： VALENTA, Rudolf ,  VRTALA, Susanne ,  STUMMVOLL, Sabine ,  GRÖNLUND, Hans ,  GROTE, Monika ,  VANGELISTA, Luca ,  PASTORE, Annalisa, c/o Molecular Structure Div ,  SPERR, Wolfgang, R. ,  VALENT, Peter ,  KRAFT, Dietrich

IPC分类号： C07K14/415 ,  A61K39/36 ,  A61P37/08

CPC分类号： A61K39/36 ,  A61K38/00 ,  A61K39/00 ,  C07K14/415

摘要： The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity. The invention also relates to a hypoallergenic immunogenic combination of molecules derived from the Phl p 6 allergen, comprising: (i) a Phl p 6 molecule having an N-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, and (ii) a Phl p 6 molecule having a C-terminal deletion which makes the molecule at least substantially lack IgE binding capacity, which two molecules together encompass the complete sequence of Phl p 6. The invention further relates to the use of the hypoallergenic immunogenic molecule or molecule mixture in hyposensitization and diagnosis.

公开(公告)号：EP0763059B2

公开(公告)日：2010-07-28

申请号：EP95922855.2

申请日：1995-06-14

申请人： Phadia AB

发明人： BALL, Tanja ,  VRTALA, Susanne ,  SPERR, Wolfgang ,  VALENT, Peter ,  SUSANI, Markus ,  KRAFT, Dietrich ,  VALENTA, Rudolf ,  LAFFER, Sylvia

IPC分类号： C07K14/415 ,  C12N15/29 ,  A61K39/36 ,  C07K14/735

CPC分类号： C07K14/415 ,  A61K38/00 ,  C07K2319/00

公开(公告)号：EP1019085B1

公开(公告)日：2009-03-04

申请号：EP98946774.1

申请日：1998-09-30

申请人： Phadia AB

发明人： VALENTA, Rudolf ,  VRTALA, Susanne ,  VANGELISTA, Luca ,  EICHLER, Hans-Georg ,  SPERR, Wolfgang, R. ,  VALENT, Peter ,  EBNER, Christof ,  KRAFT, Dietrich ,  GRÖNLUND, Hans

IPC分类号： A61K39/35 ,  C07K14/00

CPC分类号： C07K16/16 ,  A61K39/00 ,  C07K14/415 ,  Y10S530/868

公开(公告)号：EP2673292A1

公开(公告)日：2013-12-18

申请号：EP12745221.7

申请日：2012-02-08

申请人： Phadia AB

发明人： SCHMIDHUBER, Alexandra ,  VALENTA, Rudolf ,  PAHR, Sandra ,  SRINIVASAN, Bharani ,  VRTALA, Susanne

IPC分类号： C07K14/415 ,  A61K38/16 ,  A61P37/00 ,  G01N33/68

CPC分类号： C07K14/415 ,  A61K38/00 ,  G01N33/5008 ,  G01N33/6893 ,  G01N2800/202 ,  G01N2800/24

摘要： The present invention relates to the field of different wheat hypersensitivities, particularly with antigens and peptides for discrimination of different forms of these diseases. The invention relates to the identification of novel wheat allergens and the use thereof in therapy and diagnosis of celiac disease, dermatitis herpetiformis, and IgE-mediated allergy. Furthermore, the present invention provides the use of known peptides and proteins in therapy and diagnosis. The invention also relates to methods for diagnosis and treatment of celiac disease, dermatitis herpetiformis, and IgE-mediated allergy.

公开(公告)号：EP0763059B1

公开(公告)日：2007-08-29

申请号：EP95922855.2

申请日：1995-06-14

申请人： Phadia AB

发明人： BALL, Tanja ,  VRTALA, Susanne ,  SPERR, Wolfgang ,  VALENT, Peter ,  SUSANI, Markus ,  KRAFT, Dietrich ,  VALENTA, Rudolf ,  LAFFER, Sylvia

IPC分类号： C07K14/415 ,  C12N15/29 ,  A61K39/36 ,  C07K14/735

CPC分类号： C07K14/415 ,  A61K38/00 ,  C07K2319/00

摘要： A recombinant DNA molecule comprising a nucleotide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in figure 2 and preferably being derived from grasses or monocotyledonic plants, or a nucleotide sequence (II) which hybridizes with such a nucleotide sequence (I) under conditions of high stringency. Polypeptides displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in figure 2. Recombinant expression vectors containing the recombinant molecule and host cells transformed with the vector. Diagnostic methods based on utilizing the polypeptides in immunoassays for humoral antibodies and cellular reactions.