公开(公告)号：EP3265084A4

公开(公告)日：2018-08-01

申请号：EP16759417

申请日：2016-03-02

申请人： PHARMACYCLICS LLC

发明人： ATLURI HARISHA ,  CHONG CHING WAH ,  KUEHL ROBERT ,  TAN HEOW

IPC分类号： A61K31/436 ,  A61K31/519

CPC分类号： A61K9/2054 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2095 ,  A61K31/519

摘要： Described herein are pharmaceutical formulations of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Also disclosed are methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

公开(公告)号：EP3193877A4

公开(公告)日：2018-04-04

申请号：EP15829513

申请日：2015-08-07

申请人： PHARMACYCLICS LLC

发明人： TAY PEARL SHWE CHO ,  MINIKIS RYAN MITCHELL ,  HULVAT JAMES FRANCIS ,  MCVEY ALEXANDER JACOB ,  SHU CASSANDRA ,  ATLURI HARISHA ,  KUEHL ROBERT ,  CHONG CHING WAH

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/26 ,  A61K31/519

CPC分类号： A61K31/519 ,  A61K9/10 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2077 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38

摘要： Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.