专利检索 ap:("PHARMACYCLICS LLC" OR "JANSSEN PHARMACEUTICA NV") AND inv:"KUO HSU PING" 第 1 页

1.

发明公开
BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS AND USES THEREOF 审中-公开

公开(公告)号：EP3177366A4

公开(公告)日：2018-04-04

申请号：EP15829601

申请日：2015-08-06

申请人： PHARMACYCLICS LLC , JANSSEN PHARMACEUTICA NV

发明人： BALASUBRAMANIAN SRIRAM , KUO HSU PING , HSIEH HSIN KANG , CHANG BETTY , XUE LING , CHEUNG LEO

IPC分类号： A61P35/02 , A61K31/4164 , A61K31/4196 , A61K31/426 , A61K31/454 , A61K31/519 , A61K31/69 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/31 , A61K45/06

CPC分类号： A61K31/519 , A61K31/4164 , A61K31/4196 , A61K31/426 , A61K31/454 , A61K31/69 , A61K38/005 , A61K38/191 , A61K38/2013 , A61K38/21 , A61K45/06 , A61K2300/00 , A61K38/31

摘要： Disclosed herein are methods, compositions, and kits for treating a B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor. Also disclosed herein are methods, compositions, and kits for treating a BTK-resistant B-cell malignancy comprising administering a combination of a BTK inhibitor (e.g. ibrutinib) and a PIM inhibitor.