公开(公告)号：EP0499232A3

公开(公告)日：1992-12-02

申请号：EP92102335.4

申请日：1992-02-12

申请人： PLIVA Handels GmbH ,  PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA S P.O.

发明人： Kovacevic, Mice, Dr. ,  Mandic, Zorica ,  Tomic, Mirjana ,  Brkic, Zinka ,  Herak, Jure, Dr. ,  Lukic, Irena

IPC分类号： C07D205/095 ,  C07D205/09 ,  C07D403/04 ,  C07D413/12 ,  A61K31/395

CPC分类号： C07D403/04 ,  C07D205/09 ,  C07D205/095 ,  C07D413/10

摘要： The invention relates to novel 4-oxo-azetidine-2-sulfonic acids and their salts or the formula I

wherein:
R¹ = hydrogen, halogen, phenylacetamido; R² = hydrogen, halogen, phenylacetamido, phenoxyacetamido, phthalimido, 5-methyl-3- o -chlorophenyl-isoxazole-4-carboxamido; R³ = hydrogen, alkali metal, alkaline earth metal, quaternary ammonium group; R⁴ = hydrogen, SO₂O ⁻⁺ NBu₄- n ,
(CH₃)₂C=C-COOCH₃,
(CH₃)₂C=C-COOCH₂Ph,
(CH₃)₂C=C-COOCH₂-C₆H₄-NO₂- p ,
(CH₃)₂C=C-COOCH₂-C₆H₄-CH₃- m . The products (I) may be used as intermediates in the synthesis of beta-lactamic antibiotics or as components in antimicrobial preparations.

公开(公告)号：EP0499232A2

公开(公告)日：1992-08-19

申请号：EP92102335.4

申请日：1992-02-12

申请人： PLIVA Handels GmbH ,  PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA S P.O.

发明人： Kovacevic, Mice, Dr. ,  Mandic, Zorica ,  Tomic, Mirjana ,  Brkic, Zinka ,  Herak, Jure, Dr. ,  Lukic, Irena

IPC分类号： C07D205/095 ,  C07D205/09 ,  C07D403/04 ,  C07D413/12 ,  A61K31/395

CPC分类号： C07D403/04 ,  C07D205/09 ,  C07D205/095 ,  C07D413/10

摘要： The invention relates to novel 4-oxo-azetidine-2-sulfonic acids and their salts or the formula I

wherein:

R¹ = hydrogen, halogen, phenylacetamido;
R² = hydrogen, halogen, phenylacetamido, phenoxyacetamido, phthalimido, 5-methyl-3- o -chlorophenyl-isoxazole-4-carboxamido;
R³ = hydrogen, alkali metal, alkaline earth metal, quaternary ammonium group;
R⁴ = hydrogen, SO₂O ⁻⁺ NBu₄- n ,
(CH₃)₂C=C-COOCH₃,
(CH₃)₂C=C-COOCH₂Ph,
(CH₃)₂C=C-COOCH₂-C₆H₄-NO₂- p ,
(CH₃)₂C=C-COOCH₂-C₆H₄-CH₃- m .

The products (I) may be used as intermediates in the synthesis of beta-lactamic antibiotics or as components in antimicrobial preparations.

摘要翻译： 本发明涉及新的4-氧代 - 氮杂环丁烷-2-磺酸及其盐或式I worin，R <1> =氢，卤素，苯基乙酰氨基; [R <2> =氢，卤素，苯基乙酰胺基，苯氧基，苯二甲酰亚，5-甲基-3-邻氯苯基异恶唑-4-甲酰胺基; [R <3> =氢，碱金属，碱土金属，季铵基团; ř氢<4> =，SO 2 O < - > <+> NBu4-n中，（CH 3）2 C = C-COOCH 3，（CH3）2C = C-COOCH2Ph，（CH3）2C = C-COOCH 2 -C 6 H 4-NO2-P ，（CH3）2C = C-COOCH 2-C6H4-CH3米。 产物（I）可被用作在β-内酰胺抗生素的合成中的中间体或作为抗菌制剂组分。