公开(公告)号：EP1336608A4

公开(公告)日：2009-03-25

申请号：EP01982865

申请日：2001-11-20

申请人： POLA CHEM IND INC ,  TAKEUCHI TSUTOMU ,  TAKAYANAGI HIROAKI

发明人： TAKEUCHI TSUTOMU ,  TAKAYANAGI HIROAKI ,  KOBAYASHI SEIKI ,  OSA YUMIKO ,  SUZUKI YUMIKO ,  SATO YOKO ,  SAKAGUCHI M ,  MIYATA Y

IPC分类号： C07D295/088 ,  A61K31/495 ,  A61P33/06 ,  A61P43/00 ,  C07D241/04 ,  C07D295/084

CPC分类号： C07D295/088 ,  A61K31/495 ,  C07D295/084 ,  A61K31/00 ,  A61K2300/00

摘要： Dibenzosuberanyl piperazine derivatives represented by the following formula (I): wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof. These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.

公开(公告)号：EP1801231A4

公开(公告)日：2008-05-21

申请号：EP05783483

申请日：2005-09-14

申请人： KOWA CO ,  TAKEUCHI TSUTOMU ,  TSUZAKA KENSEI ,  YOSHIMOTO KEIKO

发明人： TAKEUCHI TSUTOMU ,  TSUZAKA KENSEI ,  YOSHIMOTO KEIKO

IPC分类号： C12Q1/02 ,  A61K31/341 ,  A61K39/395 ,  A61P43/00 ,  C12Q1/68

CPC分类号： C07K16/2875 ,  A61K31/341 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/6863 ,  G01N2500/00

摘要： A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable of suppressing the expression or activity of BAFF which comprises adding a test substance to a BAFF-production system prepared by adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell and measuring the expression amount and/or the activity of BAFF in the BAFF-production system; and a BAFF production inducer for a BAFF-producing cell which contains a combination of TPA with ionomycin and/or an anti-CD3 antibody.

公开(公告)号：EP1826218A4

公开(公告)日：2009-11-25

申请号：EP05776879

申请日：2005-08-30

申请人： KOWA CO ,  TAKEUCHI TSUTOMU ,  YOSHIMOTO KEIKO

发明人： TAKEUCHI TSUTOMU ,  YOSHIMOTO KEIKO

IPC分类号： C07K16/24 ,  A61K39/395 ,  A61P3/10 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00 ,  C12N15/02 ,  C12P21/08 ,  G01N33/15 ,  G01N33/53

CPC分类号： G01N33/68 ,  A61K2039/505 ,  C07K14/70575 ,  C07K16/241 ,  G01N33/564 ,  G01N33/74 ,  G01N2500/00