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1.发明公开SUBSTITUTED AROMATIC COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, LIVER FIBROSIS, SKIN FIBROSIS AND CARDIAC FIBROSIS 审中-公开取代芳香族化合物治疗肺纤维化，肝纤维化，皮肤纤维化及心脏纤维化
公开(公告)号：EP2970088A4
公开(公告)日：2016-10-19
申请号：EP14762607
申请日：2014-03-14
发明人： GAGNON LYNE , LAURIN PIERRE , GROUIX BRIGITTE , GEERTS LILIANNE , SARRA-BOURNET FRANÇOIS , LEDUC MARTIN , ABBOTT SHAUN , ZACHARIE BOULOS , BIENVENU JEAN-FRANÇOIS , PERRON VALÉRIE
IPC分类号： C07C59/52 , A61K31/192 , A61K31/4418 , A61P11/00 , A61P19/04 , C07C57/30 , C07C57/58
CPC分类号： C07C57/30 , A61K31/192 , A61K31/4418 , A61K45/06 , C07C57/42 , C07C57/58 , C07C57/60 , C07C59/52 , C07C59/84
摘要： The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, OH or F; R2 is H, OH, F or CH2—OH; R3 is H, OH, F or CH2Ph; R4 is H, OH or F; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH.
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2.发明公开
公开(公告)号：EP3217968A4
公开(公告)日：2018-06-20
申请号：EP15859768
申请日：2015-11-12
发明人： GAGNON LYNE , LAURIN PIERRE
IPC分类号： A61K31/192 , A61K8/36 , A61P17/02 , A61P19/08 , A61Q19/08 , C07C57/30 , C07C57/32 , C07C57/58 , C07C59/52 , C07C59/84
CPC分类号： A61K31/192 , A61K8/36 , A61K8/365 , A61P17/02 , A61P19/08 , A61Q19/08 , C07C57/30 , C07C57/32 , C07C57/58 , C07C59/52 , C07C59/84
摘要： Described herein are compounds of Formula I, or pharmaceutically acceptable salts thereof, or combinations thereof, as well as uses thereof. Such uses include promoting tissue self-repair or tissue regeneration of an organ, stimulating the generation of tissue growth, modulating (e.g. increasing) the level of a tissue-repair marker, treating physical injury in an organ, tissue, or cell, promoting wound healing as well as anti-aging applications. Corresponding compositions, methods and uses are also described. Formula I wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F of OH; R2 is H, F, OH, C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH, or CH2Ph; R4 is H, F or OH; Q is 1) (CH2),C(0)OH wherein m is 1 or 2 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)-C(0)OH, 5) CF2-C(0)OH or 6) C(0)-C(0)OH.
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3.发明公开SUBSTITUTED AROMATIC COMPOUNDS AND RELATED METHOD FOR THE TREATMENT OF FIBROSIS 审中-公开取代的芳香族化合物和相应的用于纤维化的治疗
公开(公告)号：EP2970089A4
公开(公告)日：2016-10-12
申请号：EP14764458
申请日：2014-03-14
发明人： ZACHARIE BOULOS , ABBOTT SHAUN , GAGNON LYNE , LAURIN PIERRE , GROUIX BRIGITTE
IPC分类号： C07C57/30 , A61K31/192 , A61P19/04 , C07C57/58 , C07C59/52
CPC分类号： C07C53/134 , A61K31/192 , C07C57/30 , C07C57/58 , C07C59/52
摘要： The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)—(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(0)OH wherein m is 1 or 2, 2) CH(CH3)C(0)OH, 3) C(CH3)2C(0)OH, 4) CH(F)—C(0)OH, 5) CF2-C(0)OH, or 6) C(0)-C(0)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.
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