公开(公告)号：EP3113619A4

公开(公告)日：2017-09-13

申请号：EP15757755

申请日：2015-03-05

申请人： PTC THERAPEUTICS INC

发明人： DALI MANDAR V ,  TAKASUGI JAMES ,  WEETALL MARLA L ,  WELCH ELLEN

IPC分类号： C07D271/06 ,  A61K9/00 ,  A61K31/4245

CPC分类号： C07D271/06 ,  A61K9/0048 ,  A61K31/4245

摘要： Provided herein are pharmaceutical compositions, which comprise a 1,2,4-oxadiazole benzoic acid or a pharmaceutically acceptable salt thereof. Further provided herein are certain pharmaceutically acceptable salts of a 1,2,4-oxadiazole benzoic acid and methods for making the same. Further provided herein are methods of treating or preventing a disease associated with a nonsense mutation or a premature stop codon, comprising administering such pharmaceutical compositions or pharmaceutically acceptable salts to a patient having a disease associated with a nonsense mutation or a premature stop codon.

摘要翻译： 本文提供了药物组合物，其包含1,2,4-恶二唑苯甲酸或其药学上可接受的盐。 本文进一步提供了1,2,4-恶二唑苯甲酸的某些药学上可接受的盐及其制备方法。 本文进一步提供了治疗或预防与无义突变或提前终止密码子有关的疾病的方法，包括将所述药物组合物或可药用盐给予患有与无义突变或提前终止密码子相关的疾病的患者。