公开(公告)号：EP1732543A2

公开(公告)日：2006-12-20

申请号：EP05733369.2

申请日：2005-03-15

申请人： PTC Therapeutics, Inc.

发明人： MOON, Young-Choon ,  CAO, Liangxian ,  TAMILARASU, Nadarajan ,  QI, Hongyan ,  CHOI, Soongyu ,  LENNOX, William, Joseph ,  CORSON, Donald, Thomas

IPC分类号： A61K31/4166 ,  A61P35/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P3/04 ,  A61P27/00 ,  A61P29/00

CPC分类号： A61K31/4166 ,  C07D221/18 ,  C07D235/02 ,  C07D239/26 ,  C07D241/04 ,  C07D265/30 ,  C07D307/78 ,  C07D317/48

摘要： In accordance with the present invention,tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

公开(公告)号：EP2417133A1

公开(公告)日：2012-02-15

申请号：EP10713288.8

申请日：2010-04-05

申请人： PTC Therapeutics, Inc.

发明人： MACCOSS, Malcolm ,  NJOROGE, F., George ,  NOMEIR, Amin ,  CHEN, Guangming ,  KARP, Gary, Mitchell ,  LENNOX, William, Joseph ,  LI, Chunshi ,  MORRILL, Christie ,  PAGET, Steven, D. ,  REN, Hongyu ,  ZHANG, Nanjing ,  ZHANG, Xiaoyan

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/519 ,  A61P31/12

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D487/04

摘要： The present invention is directed to compounds of formula (I) and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。

公开(公告)号：EP2417122A1

公开(公告)日：2012-02-15

申请号：EP10714125.1

申请日：2010-04-05

申请人： PTC Therapeutics, Inc.

发明人： MACCOSS, Malcolm ,  NJOROGE, F., George ,  NOMEIR, Amin ,  CHEN, Guangming ,  HUANG, Song, Xiao ,  KAKARLA, Ramesh ,  KARP, Gary, Mitchell ,  LENNOX, William, Joseph ,  LI, Chunshi ,  LIU, Ronggang ,  LIU, Yalei ,  MORRILL, Christie ,  PAGET, Steven, D. ,  SMITH, Sean, W. ,  TAKASUGI, James ,  TURPOFF, Anthony, A. ,  REN, Hongyu ,  ZHANG, Nanjing ,  ZHANG, Xiaoyan ,  ZHU, Jin

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61P31/12 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4436 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/506

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

公开(公告)号：EP1732543B1

公开(公告)日：2017-05-10

申请号：EP05733369.2

申请日：2005-03-15

申请人： PTC Therapeutics, Inc.

发明人： MOON, Young-Choon ,  CAO, Liangxian ,  TAMILARASU, Nadarajan ,  QI, Hongyan ,  CHOI, Soongyu ,  LENNOX, William, Joseph ,  CORSON, Donald, Thomas

IPC分类号： C07D317/48 ,  A61K31/4166 ,  A61P35/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P3/04 ,  A61P27/00 ,  A61P29/00 ,  C07D221/18 ,  C07D235/02 ,  C07D239/26 ,  C07D241/04 ,  C07D265/30 ,  C07D307/78

CPC分类号： A61K31/4166 ,  C07D221/18 ,  C07D235/02 ,  C07D239/26 ,  C07D241/04 ,  C07D265/30 ,  C07D307/78 ,  C07D317/48