公开(公告)号：EP2727915A1

公开(公告)日：2014-05-07

申请号：EP13185607.2

申请日：2008-09-12

Applicant: Concert Pharmaceuticals Inc.

Inventor： Jones, Andrew D ,  Zelle, Robert E ,  Silverman, I Robert

IPC: C07D317/48 ,  C07D405/12 ,  C07D471/14 ,  C07D491/14 ,  A61K31/4525 ,  A61K31/4745 ,  A61P35/00

CPC classification number: C07D317/46 ,  C07D317/48 ,  C07D405/12 ,  C07D471/14 ,  C07D491/14

Abstract: The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[ d ][1,3]dioxoles.

Abstract translation: 本发明提供了合成d 2 - 苯并[d] [1,3]二氧杂环戊烯的方便而有效的方法。

公开(公告)号：EP2151239A4

公开(公告)日：2010-11-24

申请号：EP07710861

申请日：2007-01-31

Applicant: GUANGZHOU ZHONGWEI BIOTECHNOLO

Inventor： WAN HUAYIN ,  LI RUBING ,  LI YONGHE ,  ZHOU LIJIAN ,  LIU TIEQIU ,  ZHONG XIAOHUI

IPC: A61K31/36 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07D317/48

CPC classification number: A61K31/36 ,  A61K9/0014 ,  A61K9/19 ,  A61K47/10 ,  A61K47/183 ,  A61K47/26 ,  C07D317/48

公开(公告)号：EP2200997A1

公开(公告)日：2010-06-30

申请号：EP08830527.1

申请日：2008-09-12

Applicant: Concert Pharmaceuticals Inc.

Inventor： JONES, Andrew, D. ,  ZELLE, Robert, E. ,  SILVERMAN, I., Robert

IPC: C07D317/48 ,  C07D405/12 ,  C07D471/14 ,  C07D491/14 ,  A61K31/4525 ,  A61K31/4745 ,  A61P35/00

CPC classification number: C07D317/46 ,  C07D317/48 ,  C07D405/12 ,  C07D471/14 ,  C07D491/14

Abstract: The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][l,3]dioxoles.

公开(公告)号：EP1732543A2

公开(公告)日：2006-12-20

申请号：EP05733369.2

申请日：2005-03-15

Applicant: PTC Therapeutics, Inc.

Inventor： MOON, Young-Choon ,  CAO, Liangxian ,  TAMILARASU, Nadarajan ,  QI, Hongyan ,  CHOI, Soongyu ,  LENNOX, William, Joseph ,  CORSON, Donald, Thomas

IPC: A61K31/4166 ,  A61P35/00 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P3/04 ,  A61P27/00 ,  A61P29/00

CPC classification number: A61K31/4166 ,  C07D221/18 ,  C07D235/02 ,  C07D239/26 ,  C07D241/04 ,  C07D265/30 ,  C07D307/78 ,  C07D317/48

Abstract: In accordance with the present invention,tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

公开(公告)号：EP1701949A2

公开(公告)日：2006-09-20

申请号：EP04813878.8

申请日：2004-12-13

Applicant: DADE BEHRING INC.

Inventor： ZHENG, Yi, Feng ,  LIU, Hshiou-Ting ,  YANG, Yali

IPC: C07D317/48 ,  A61K39/385 ,  G01N33/531 ,  C07K17/06 ,  C07K16/44 ,  G01N33/533 ,  G01N33/535

CPC classification number: C07D317/48 ,  C07D317/58 ,  C07D405/12 ,  C07K16/44 ,  G01N33/532 ,  G01N33/946

Abstract: Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA) and 4-hydroxy-3-methoxy-methamphetamine (HMMA). The method comprises providing in combination in a medium (i) a sample suspected of containing the compound and (ii) an antibody raised against a compound of Formula I that comprises a protein. The medium is examined for the presence a complex comprising the compound and the antibody where the presence of such as complex indicates the presence of the compound in the sample. In one aspect of the above embodiment, the combination further comprises a label conjugate of the compound Formula I.

公开(公告)号：EP1100483B1

公开(公告)日：2004-09-29

申请号：EP99938896.0

申请日：1999-07-30

Applicant: Abbott Laboratories

Inventor： COGHLAN, Michael, J. ,  LULY, Jay, R. ,  SCHKERYANTZ, Jeffrey, M. ,  WANG, Alan, X.

IPC: A61K31/136 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4545 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/4025 ,  A61K31/222 ,  A61K31/40 ,  A61K31/45 ,  A61K31/24 ,  A61K31/341 ,  C07D295/06 ,  C07C219/06 ,  C07C211/52 ,  C07C215/16 ,  C07C271/28 ,  C07C219/10 ,  C07C217/76 ,  C07C323/29

CPC classification number: C07C211/52 ,  C07C211/50 ,  C07C215/16 ,  C07C217/76 ,  C07C217/80 ,  C07C219/06 ,  C07C229/18 ,  C07C233/43 ,  C07C233/44 ,  C07C233/62 ,  C07C233/80 ,  C07C271/28 ,  C07C311/39 ,  C07C323/29 ,  C07C2601/02 ,  C07D317/48

Abstract: Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, adrenal imbalance, cognitive and behavioral diseases in a mammal.

公开(公告)号：EP0130829B1

公开(公告)日：1987-06-03

申请号：EP84304498.3

申请日：1984-06-29

Applicant: ROOPEROL (NA) NV

Inventor： Drewes, Siegfried ,  Liebenberg, Roelof Wilke

IPC: C07C39/21 ,  C07C43/215 ,  C07C33/00 ,  C07C15/40 ,  C07C49/225 ,  C07C69/21 ,  C07C69/618 ,  C07C25/24 ,  C07D309/12 ,  C07D317/50 ,  C07H15/20

CPC classification number: C07H15/203 ,  C07C15/48 ,  C07C15/50 ,  C07C33/042 ,  C07C33/048 ,  C07C33/20 ,  C07C33/28 ,  C07C33/48 ,  C07C33/486 ,  C07C39/21 ,  C07C43/215 ,  C07C43/23 ,  C07D233/24 ,  C07D303/04 ,  C07D307/42 ,  C07D309/12 ,  C07D317/48 ,  C07D317/50

公开(公告)号：EP2262766B1

公开(公告)日：2015-11-11

申请号：EP09716825.6

申请日：2009-02-27

Applicant: Evotec AG

Inventor： WEI, Zhi-Liang ,  GOWLUGARI, Sumithra ,  KAUB, Carl ,  WANG, Zhan ,  CAO, Yeyu ,  KINCAID, John

IPC: C07D205/04 ,  C07D213/56 ,  C07D213/61 ,  C07D215/12 ,  C07D231/12 ,  C07D231/16

CPC classification number: C07D213/64 ,  C07C69/78 ,  C07C233/69 ,  C07C317/32 ,  C07D205/04 ,  C07D207/06 ,  C07D213/56 ,  C07D213/61 ,  C07D213/643 ,  C07D215/12 ,  C07D231/12 ,  C07D231/16 ,  C07D239/26 ,  C07D239/34 ,  C07D239/47 ,  C07D241/12 ,  C07D249/08 ,  C07D263/56 ,  C07D265/36 ,  C07D277/28 ,  C07D277/30 ,  C07D295/104 ,  C07D317/48 ,  C07D333/54 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D489/04

公开(公告)号：EP2330906A4

公开(公告)日：2014-07-09

申请号：EP09807350

申请日：2009-08-14

Applicant: UNIV LOUISVILLE RES FOUND ,  UNIV PERUMA CAYETANO HEREDIA ,  INST RECH DEVELOPPEMENT IRD ,  UNIV JOHNS HOPKINS

Inventor： HAMMOND GERALD B ,  APONTE JOSE C ,  GILMAN ROBERT H ,  SAUVAIN MICHEL HENRI-AUGUSTE ,  VAISBERG ABRAHAM

IPC: C07C49/84 ,  A01N43/62 ,  C07C45/62 ,  C07C45/67 ,  C07C45/71 ,  C07C45/74 ,  C07D495/04

CPC classification number: C07C49/84 ,  C07C45/62 ,  C07C45/673 ,  C07C45/71 ,  C07C45/74 ,  C07D317/48 ,  C07D495/04

Abstract: Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

Abstract translation: 本发明的实施方案提供化合物（例如式（I）化合物，式（II）化合物及其各种实施方案）。 还提供了包含那些化合物的组合物。 包括其准备方法。 此外，包括化合物的用途，例如施用和治疗疾病（例如癌症和感染）。

公开(公告)号：EP1379498B1

公开(公告)日：2011-02-16

申请号：EP01958247.7

申请日：2001-08-21

Applicant: MERCK SHARP & DOHME LTD.

Inventor： CASTRO PINEIRO, Jose Luis ,  CHURCHER, Ian ,  DINNELL, Kevin ,  HARRISON, Timothy ,  KERRAD, Sonia ,  NADIN, Alan John ,  OAKLEY, Paul Joseph ,  OWENS, Andrew Pate ,  SHAW, Duncan Edward ,  TEALL, Martin Richard ,  WILLIAMS, Brian John ,  WILLIAMS, Susannah

IPC: C07C317/46 ,  C07C317/24 ,  C07D295/08 ,  C07C317/30 ,  C07D211/62 ,  C07D241/06 ,  C07D211/18 ,  C07D211/72 ,  C07D217/20 ,  C07D211/78 ,  C07D207/24 ,  C07D309/28 ,  C07D295/18 ,  C07D211/46 ,  C07D211/42

CPC classification number: C07D207/27 ,  C07C317/14 ,  C07C317/20 ,  C07C317/24 ,  C07C317/30 ,  C07C317/46 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07D207/12 ,  C07D207/404 ,  C07D211/18 ,  C07D211/42 ,  C07D211/46 ,  C07D211/54 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/64 ,  C07D213/65 ,  C07D231/12 ,  C07D233/32 ,  C07D233/40 ,  C07D233/56 ,  C07D233/64 ,  C07D241/18 ,  C07D249/04 ,  C07D249/08 ,  C07D249/12 ,  C07D257/04 ,  C07D263/38 ,  C07D263/44 ,  C07D271/06 ,  C07D277/26 ,  C07D285/12 ,  C07D295/088 ,  C07D295/096 ,  C07D295/182 ,  C07D307/52 ,  C07D309/08 ,  C07D309/10 ,  C07D317/48 ,  C07D317/72 ,  C07D491/10 ,  C07F7/0812

Abstract: Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of g-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.