公开(公告)号：EP3718405A1

公开(公告)日：2020-10-07

申请号：EP20176586.4

申请日：2010-05-27

申请人： PTC Therapeutics, Inc.

发明人： ALMSTEAD, Neil ,  ARASU, Tamil ,  CHOI, Soongyu ,  CAO, Liangxian ,  CAMPBELL, Jeff ,  CORSON, Don ,  DAVIS, Thomas, W. ,  GRACI, Jason D. ,  GU, Zhengxian ,  HWANG, Peter Seongwoo ,  LENNOX, William ,  MIAO, Harry H. ,  MILLER, Langdon ,  MOON, Young-Choon ,  QI, Hongyan ,  TROTTA, Christopher ,  WEETALL, Marla L.

IPC分类号： A01N43/42 ,  A61K31/44 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61K31/437 ,  C07D471/04

摘要： Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replications or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one ore more additional therapies to a human in need of such treatment.