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公开(公告)号：EP2797592A1
公开(公告)日：2014-11-05
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353
CPC分类号： C07D487/04 , C07D231/12 , C07D311/16 , C07D311/18 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
摘要翻译： 本文提供了化合物，其组合物以及用于治疗脊髓性肌萎缩的用途。 在具体的实施方案中，本文提供了可用于调节SMN2的外显子7包含到从SMN2基因转录的mRNA中的形式的化合物。 在另一个具体的实施方案中，本文提供了可用于调节SMN1的外显子7包含到从SMN1基因转录的mRNA中的形式的化合物。 在又一个实施方案中，本文提供了可用于调节SMN1和SMN2的外显子7包含在分别从SMN1和SMN2基因转录的mRNA中的形式的化合物。
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公开(公告)号：EP4244362A1
公开(公告)日：2023-09-20
申请号：EP21824134.7
申请日：2021-11-11
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公开(公告)号：EP4241772A2
公开(公告)日：2023-09-13
申请号：EP23169721.0
申请日：2015-05-11
IPC分类号： A61K31/5025
摘要： The present invention provides compounds of formula (I)
wherein A, R 1 , R 2 and R 3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.-
公开(公告)号：EP2809322B9
公开(公告)日：2019-10-30
申请号：EP13740919.9
申请日：2013-01-25
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公开(公告)号：EP2809322B1
公开(公告)日：2019-05-15
申请号：EP13740919.9
申请日：2013-01-25
发明人： CHEN, Guangming , DAKKA, Amal , KARP, Gary Mitchell , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , WEETALL, Marla L. , WELCH, Ellen , ZHAO, Xin
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP3911418A1
公开(公告)日：2021-11-24
申请号：EP20706032.8
申请日：2020-01-15
IPC分类号： A61P35/02 , A61K31/4184 , A61K31/407 , A61K45/06
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公开(公告)号：EP3143025B1
公开(公告)日：2019-10-09
申请号：EP15721701.9
申请日：2015-05-11
IPC分类号： C07D487/04 , C07D519/00 , A61K31/5025 , A61P21/00
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公开(公告)号：EP2797592B1
公开(公告)日：2019-08-28
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353 , C07D413/14 , C07D405/14 , C07D311/16 , C07D311/18 , C07D231/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00 , A61P25/00 , C07D417/14
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公开(公告)号：EP2809322A1
公开(公告)日：2014-12-10
申请号：EP13740919.9
申请日：2013-01-25
发明人： CHEN, Guangming , DAKKA, Amal , KARP, Gary Mitchell , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , WEETALL, Marla L. , WELCH, Ellen , ZHAO, Xin , WEETAL, Marla L.
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP4241772A3
公开(公告)日：2023-11-15
申请号：EP23169721.0
申请日：2015-05-11
IPC分类号： C07D487/04 , C07D519/00 , A61K31/5025 , A61P21/00
摘要： The present invention provides compounds of formula (I)
wherein A, R 1 , R 2 and R 3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
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