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公开(公告)号:EP0891165A4
公开(公告)日:2000-04-05
申请号:EP97917752
申请日:1997-03-31
发明人: WHITSON BRYAN , CHENG BOYLE , BADYLAK STEPHEN F
CPC分类号: A61L27/3683 , A61F2/02 , A61F2240/001 , A61L27/3629
摘要: A perforated unitary multi-laminar tissue graft construct and method for preparing such construct are described. The method comprises overlapping strips of submucosal tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosal sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.