公开(公告)号：EP2010529A1

公开(公告)日：2009-01-07

申请号：EP07719522.0

申请日：2007-04-10

申请人： PainCeptor Pharma Corp.

发明人： VOHRA, Rahul ,  WEI, Chang-Qing ,  GAN, Zhonghong ,  DEMNITZ, Joachim ,  AHRING, Philip K.

IPC分类号： C07D471/04 ,  A61K31/472 ,  A61K31/4745

CPC分类号： C07D471/04 ,  C07D209/40

摘要： The alleged invention relates to indole derivatives according to formula 1, namely, wherein X is CH2, O, NR2 or NOR2 and wherein A is preferably a six membered ring involving a nitrogen heteroatom. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.

摘要翻译： 所述发明涉及根据式1的吲哚衍生物，即其中X是CH 2，O，NR 2或NOR 2，并且其中A优选是涉及氮杂原子的六元环。 这些化合物及其药学上可接受的盐用于调节门控离子通道以治疗疼痛，炎性病症，神经病症或与泌尿生殖系统或胃肠系统相关的疾病。

公开(公告)号：EP2010497A1

公开(公告)日：2009-01-07

申请号：EP07719524.6

申请日：2007-04-10

申请人： PainCeptor Pharma Corp.

发明人： VOHRA, Rahul ,  GAN, Zhonghong ,  WEI, Chang-Qing ,  PRICE, Stephen ,  DYKE, Hazel, Joan ,  DECHAUX, Elsa, Amandine

IPC分类号： C07D217/04 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04

CPC分类号： C07D471/04 ,  C07D209/40

摘要： The present invention relates to compounds of the Formula (I),(II), (III), (IV) or (V) useful to modulate the activity of gated ion channels. The invention further relates to methods wherein said compounds are used to modulate gated ion channels comprised of at least one subunit which is a member of the DEG/ENaC, P2X or TRPV gene superfamilies. The activity of the gated ion channels which are modulated by compounds I-V are associated with pain, inflammatory disorders or neurological disorders.

公开(公告)号：EP1968968A1

公开(公告)日：2008-09-17

申请号：EP06840532.3

申请日：2006-12-21

申请人： PainCeptor Pharma Corp.

发明人： VOHRA, Rahul ,  BABINSKI, Kazimierz ,  BROCHU, Jean-Louis ,  NTIRAMPEBURA, Deogratias ,  WEI, Chang-Qing ,  ZAMBONI, Robert, Joseph ,  REAYI, Ayub, A.

IPC分类号： C07D401/12 ,  A61K31/47 ,  A61K31/496 ,  A61K31/517 ,  A61K31/551 ,  A61P25/00 ,  A61P29/00 ,  C07D215/52 ,  C07D239/74 ,  C07D239/88 ,  C07D239/91 ,  C07D239/94 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14

CPC分类号： C07D239/91 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/551 ,  C07D215/233 ,  C07D215/44 ,  C07D215/46 ,  C07D215/52 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

摘要： Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4- position via N(H), C(O) or O moieties.