公开(公告)号：EP1968968A1

公开(公告)日：2008-09-17

申请号：EP06840532.3

申请日：2006-12-21

申请人： PainCeptor Pharma Corp.

发明人： VOHRA, Rahul ,  BABINSKI, Kazimierz ,  BROCHU, Jean-Louis ,  NTIRAMPEBURA, Deogratias ,  WEI, Chang-Qing ,  ZAMBONI, Robert, Joseph ,  REAYI, Ayub, A.

IPC分类号： C07D401/12 ,  A61K31/47 ,  A61K31/496 ,  A61K31/517 ,  A61K31/551 ,  A61P25/00 ,  A61P29/00 ,  C07D215/52 ,  C07D239/74 ,  C07D239/88 ,  C07D239/91 ,  C07D239/94 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14

CPC分类号： C07D239/91 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/551 ,  C07D215/233 ,  C07D215/44 ,  C07D215/46 ,  C07D215/52 ,  C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

摘要： Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4- position via N(H), C(O) or O moieties.