公开(公告)号：EP1449849A3

公开(公告)日：2006-01-25

申请号：EP04009293.4

申请日：1993-02-05

申请人： Paion Deutschland GmbH

发明人： Light, David Richard ,  Andrews, William H. ,  Clarke, Jeffrey Homer ,  Wydro, Robert Michael ,  Young, Patricia Ann

IPC分类号： C07K14/745 ,  C12N15/12 ,  A61K38/36

CPC分类号： C07K14/7455 ,  A61K38/00

摘要： The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.