公开(公告)号：EP0829267A1

公开(公告)日：1998-03-18

申请号：EP97116409.0

申请日：1990-12-20

申请人： Pall Corporation

发明人： Carmen, Raleigh A. ,  Nelson, Edward J.

IPC分类号： A61M1/34

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/0071 ,  A61M2202/005

摘要： Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter (11) disposed between a first blood bag (3) and at least two empty secondary bags (15a,15b). A fourth bag (17) may be included in the closed system to contain a platelet additive solution. System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.

摘要翻译： 直接从富血小板血浆（PRP）过滤白细胞（WBC），而不是随后制备血小板浓缩物（PC）。 早期过滤对于以最小的血小板损失去除大多数WBC是有效的，并允许血小板储存至少5天。 过滤优选用封闭的即用型系统完成，该系统包括布置在第一血袋（3）和至少两个空的次级袋（15a，15b）之间的WBC过滤器（11）。 第四袋（17）可以包括在封闭系统中以容纳血小板添加剂溶液。 系统可以去除至少95％的血小板少于10％的WBC。 在非常优选的实施方案中，在血小板储存之前通过过滤除去至少99.5％的原始WBC。

公开(公告)号：EP0484751A1

公开(公告)日：1992-05-13

申请号：EP91118131.1

申请日：1991-10-24

申请人： Pall Corporation

发明人： Baumann, Ronald H. ,  Denton, Donald R. ,  Dupin, William W. ,  Nelson, Edward J. ,  Sajan, Eva

IPC分类号： A61J1/10

CPC分类号： A61M1/0209 ,  A61M2039/222

摘要： Plastic blood bag system including a bag (3) having a generally longitudinal seal (3f) extending from the top of the bag (3) and between two blood bag ports (17a,27a) downwardly to at least the lower half of the bag (3) but not to the bottom of the bag (3), thereby leaving the sole passageway (3d) within the bag (3) and between two ports (17a,27a) located in the lower half of the bag (3).
In one use, whole blood is introduced into the bag (3) and then centrifuged to form a lighter plasma portion (9) and a more dense red blood portion (11). The red blood cell portion (11) can then be removed from the lower part of the bag (3) by applying pressure to the bag (3) to push substantially all of the red blood cells through the passageway (3d) to one side of the longitudinal seal (3f) and out of the bag (3) through the port (17a) communicating with that side of the longitudinal seal (3f).
In preferred embodiments, the longitudinal seal (3f) is generally parallel and close to one edge of the bag (3) and terminates at its lower portion within the lower 10% of the bag length. In very preferred embodiments, the volume of the side through which the more dense component exits the bag (3) is less than 10% of the total bag volume. The preferred system may be used as part of a closed multiple blood bag system with electronic monitoring means to provide semi-automated blood separation.

摘要翻译： 塑料血液袋系统包括具有从袋（3）的顶部延伸并且在两个血袋端口（17a，27a）之间延伸到袋的至少下半部的大致纵向密封件（3f）的袋（3） 3），而不是袋（3）的底部，从而将鞋底通道（3d）留在袋（3）内并且位于袋（3）的下半部的两个端口（17a，27a）之间。 在一次使用中，将全血引入袋（3）中，然后离心以形成更轻的等离子体部分（9）和更致密的红血部分（11）。 然后可以通过向袋（3）施加压力以将基本上所有的红细胞通过通道（3d）推到一侧，从而从袋（3）的下部移除红细胞部分（11） 所述纵向密封件（3f）通过与所述纵向密封件（3f）的所述侧面连通的所述端口（17a）离开所述袋子（3）。 在优选实施例中，纵向密封件（3f）大致平行并靠近袋子（3）的一个边缘，并且在袋子长度的下部10％内终止于其下部分。 在非常优选的实施方案中，更密集组分离开袋（3）的一侧的体积小于总袋体积的10％。 优选的系统可以用作具有电子监测装置以提供半自动血液分离的封闭多血袋系统的一部分。

公开(公告)号：EP0442114A3

公开(公告)日：1992-01-29

申请号：EP90124842.7

申请日：1990-12-20

申请人： Pall Corporation

发明人： Carmen, Raleigh A. ,  Nelson, Edward J.

IPC分类号： A61M1/34

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/0071 ,  A61M2202/005

摘要： Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter (11) disposed between a first blood bag (3) and at least two empty secondary bags (15a,15b). A fourth bag (21) may be included in the closed system to contain a platelet additive solution (17). System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.

公开(公告)号：EP0442114B1

公开(公告)日：1998-04-15

申请号：EP90124842.7

申请日：1990-12-20

申请人： Pall Corporation

发明人： Carmen, Raleigh A. ,  Nelson, Edward J.

IPC分类号： A61M1/02

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/0071 ,  A61M2202/005

公开(公告)号：EP0442114A2

公开(公告)日：1991-08-21

申请号：EP90124842.7

申请日：1990-12-20

申请人： Pall Corporation

发明人： Carmen, Raleigh A. ,  Nelson, Edward J.

IPC分类号： A61M1/34

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/0071 ,  A61M2202/005

摘要： Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter (11) disposed between a first blood bag (3) and at least two empty secondary bags (15a,15b). A fourth bag (21) may be included in the closed system to contain a platelet additive solution (17). System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.

摘要翻译： 直接从富血小板血浆（PRP）过滤白细胞（WBC），而不是随后制备血小板浓缩物（PC）。 早期过滤对于以最小的血小板损失去除大多数WBC是有效的，并允许血小板储存至少5天。 过滤优选用封闭的即用型系统完成，该系统包括布置在第一血袋（3）和至少两个空的次级袋（15a，15b）之间的WBC过滤器（11）。 第四袋（21）可以包括在封闭系统中以容纳血小板添加剂溶液（17）。 系统可以去除至少95％的血小板少于10％的WBC。 在非常优选的实施方案中，在血小板储存之前通过过滤除去至少99.5％的原始WBC。

公开(公告)号：EP0829267B1

公开(公告)日：2001-08-29

申请号：EP97116409.0

申请日：1990-12-20

申请人： Pall Corporation

发明人： Carmen, Raleigh A. ,  Nelson, Edward J.

IPC分类号： A61M1/34

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0042 ,  A61M2202/0071 ,  A61M2202/005

公开(公告)号：EP0484751B1

公开(公告)日：1995-12-20

申请号：EP91118131.1

申请日：1991-10-24

申请人： Pall Corporation

发明人： Baumann, Ronald H. ,  Denton, Donald R. ,  Dupin, William W. ,  Nelson, Edward J. ,  Sajan, Eva

IPC分类号： A61J1/10

CPC分类号： A61M1/0209 ,  A61M2039/222

公开(公告)号：EP0536594A1

公开(公告)日：1993-04-14

申请号：EP92116319.2

申请日：1992-09-24

申请人： Pall Corporation

发明人： Nelson, Edward J.

IPC分类号： A61J1/00

CPC分类号： A61M1/0209 ,  A61M1/0218 ,  A61M2039/222 ,  A61M2202/0429 ,  A61M2202/0431 ,  A61M2202/0439 ,  A61M2202/0071 ,  A61M2202/005 ,  A61M2202/0042

摘要： A generally flat, elongated edge-sealed polymeric blood bag (33) having a length to width ratio of at least 2 to 1 and one end portion (12) in tapering communication with a connected single tubing (31) which in turn is in closed communication via a Y-connector (35) with both a bag access port (3) and at least one other Y-connector (45). The second Y-connector (45) is in closed communication with at least one auxiliary bag (39), preferably two auxiliary bags (39,41). Once the upper neocyte portion is expressed from the elongated blood bag the lower, more dense gerocytes can be saved in the original elongated bag or expressed into another connected bag via the Y-connector assembly for subsequent use or storage. The bag system is especially useful for separating and isolating both components of a neocyte/gerocyte red blood cell mixture in an open system and for providing a means for saving the otherwise discarded gerocytes for subsequent use. A physiological solution can be introduced via the Y-connector assemblies into the elongated bag to reconstitute the dense gerocytes.

摘要翻译： 具有至少2比1的长宽比的大致平坦的，细长的边缘密封聚合血袋（33）和与连接的单个管道（31）成锥形连通的一个端部部分（12），所述单个管道（31）又被关闭 通过具有袋入口（3）和至少一个其它Y型连接器（45）的Y型连接器（35）进行通信。 第二Y型连接器（45）与至少一个辅助袋（39），优选两个辅助袋（39,41）密封连通。 一旦从细长的血袋表达上部新细胞部分，下部更密集的巨细胞可以保存在原始的细长袋中，或者通过Y型连接器组件被表达到另一个连接的袋中，用于随后的使用或储存。 袋系统特别可用于在开放系统中分离和分离新细胞/巨细胞红血细胞混合物的两种成分，并提供用于保存另外丢弃的大豆细胞以供随后使用的方法。 可以通过Y型连接器组件将生理溶液引入细长袋中以重构密集的细胞。