公开(公告)号：EP3403659A1

公开(公告)日：2018-11-21

申请号：EP18020251.7

申请日：2011-03-11

申请人： Regen Lab SA

发明人： TURZI Antonie

IPC分类号： A61K35/14 ,  A61K35/16 ,  A61K38/48

CPC分类号： A61K38/4833 ,  A61K8/981 ,  A61K8/983 ,  A61K31/728 ,  A61K35/14 ,  A61K35/15 ,  A61K35/16 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K38/363 ,  A61L26/0057 ,  A61L26/0066 ,  A61L2300/30 ,  A61L2300/412 ,  A61M1/0209 ,  A61M1/029 ,  A61M5/19 ,  A61M2202/0425 ,  A61M2202/0427 ,  A61Q19/08 ,  C12Y304/21005 ,  A61K2300/00

摘要： The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.

公开(公告)号：EP2310851B1

公开(公告)日：2018-11-07

申请号：EP09803332.7

申请日：2009-06-30

申请人： Terumo BCT, Inc.

发明人： STANTON, Briden, Ray ,  VAN WAEG, Geert

IPC分类号： G01N33/49 ,  C12Q1/02 ,  A61M1/02 ,  A61M1/36

CPC分类号： G01N33/491 ,  A61M1/0272 ,  A61M1/3696 ,  A61M2202/0427

摘要： Method and Apparatus for predicting the yield of a selected cellular component from a composite blood product by sensing the movement of the separated cellular component or another component during expression from a separation container to a collection container to produce a signal indicative of the movement, and predicting the yield of the separated cellular component from the signal.

公开(公告)号：EP3342435A1

公开(公告)日：2018-07-04

申请号：EP16841657.6

申请日：2016-08-25

申请人： Terumo Kabushiki Kaisha

发明人： IGARASHI, Masatsugu

IPC分类号： A61M1/02

CPC分类号： B04B5/0442 ,  A61M1/02 ,  A61M1/0281 ,  A61M1/029 ,  A61M2202/0415 ,  A61M2202/0427

摘要： A container (58) constitutes a platelet separator (tertiary separator (42)) separating a platelet-containing component into platelets and another component by applying a centrifugal force. An inflow portion (77α) configured to allow the platelet-containing component to flow into a third chamber (52) and configured to allow a platelet additive solution to flow in and an accommodating portion (54a) accommodating the platelets are disposed in the container (58). Also disposed in the container (58) are an opening (78a) of an outflow port (78) allowing at least an outflow of the other component and an opening (79a) of a recovery port (79) disposed in a place different than the opening (78a) and recovering the platelets and the platelet additive solution.

公开(公告)号：EP3302601A2

公开(公告)日：2018-04-11

申请号：EP16731662.9

申请日：2016-06-01

申请人： Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico ,  Episkey S.r.l.

发明人： MAZZARO, Giovanni ,  REBULLA, Paolo ,  PARATI, Eugenio

IPC分类号： A61M1/02 ,  A61M1/36 ,  A61J1/20 ,  B65D75/58 ,  C12M1/00 ,  C12M1/26 ,  C12N5/00

CPC分类号： A61J1/10 ,  A61J1/20 ,  A61J1/2024 ,  A61J1/2027 ,  A61K35/16 ,  A61K35/19 ,  A61M1/0209 ,  A61M1/0236 ,  A61M1/0272 ,  A61M1/029 ,  A61M1/3693 ,  A61M2202/0427 ,  A61M2202/0437 ,  A61M2202/0462 ,  B65D75/5816 ,  B65D75/5827 ,  B65D75/5838 ,  C12M23/14 ,  C12M25/14 ,  C12M33/00 ,  C12M33/10 ,  C12N5/00 ,  C12N5/0644

摘要： The present invention relates to a biomedical device for the production, storage, traceability and administration of blood components.

公开(公告)号：EP3174584A4

公开(公告)日：2018-04-04

申请号：EP15827303

申请日：2015-07-29

申请人： EDENHOFFER PETER

发明人： EDENHOFFER PETER

IPC分类号： A61M11/00 ,  A61M16/00

CPC分类号： A61M16/201 ,  A61M11/00 ,  A61M11/02 ,  A61M11/06 ,  A61M16/0006 ,  A61M16/0063 ,  A61M16/06 ,  A61M16/0683 ,  A61M16/0875 ,  A61M16/1065 ,  A61M16/14 ,  A61M16/208 ,  A61M2016/0024 ,  A61M2016/0027 ,  A61M2202/0427 ,  A61M2202/0437 ,  A61M2202/07 ,  A61M2205/3331

摘要： A respiratory system includes a pressurized gas source coupled to a nebulizer containing a medicament. The nebulizer is connected to a breathing unit. A pressure sensitive switch detects negative pressure at the breathing unit due to inspiration and opens to provide pressured gas flow to the nebulizer. The pressure sensitive switch is configured to close prior to the end of inspiration. Residual medicament disposed in the system is cleared from the system and delivered to the patient during the remainder of the inspiration cycle. A compressor provides positive pressure to aid delivery of medicaments to the patient.

公开(公告)号：EP3299042A1

公开(公告)日：2018-03-28

申请号：EP17190364.4

申请日：2017-09-11

申请人： Fenwal, Inc.

发明人： PRENDERGAST, Jonathan W. ,  NGUYEN, Lan T. ,  RADWANSKI, Katherine N.

IPC分类号： A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  A61M1/38

CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3496 ,  A61M1/361 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/385 ,  A61M2202/0427 ,  A61M2202/0439 ,  A61M2202/0443 ,  B01D63/16

摘要： A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.

摘要翻译： 一种收集单核细胞的方法，包括将全血分离成悬浮在血浆中的细胞成分和血小板，将悬浮在血浆中的血小板分离成血小板浓缩物和贫血小板血浆，将细胞成分与贫血小板血浆混合形成第一混合物 并将第一混合物分离成单核细胞和至少一种组分。

公开(公告)号：EP3047864B1

公开(公告)日：2018-03-07

申请号：EP15152110.1

申请日：2015-01-22

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  University of Southern California

发明人： Emerson, Jane F.

IPC分类号： A61M1/02 ,  A61M1/36 ,  G01N33/49 ,  B01L3/00

CPC分类号： A61M1/3693 ,  A61J1/065 ,  A61J1/1406 ,  A61J1/201 ,  A61M1/029 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2202/10 ,  B01L3/50215 ,  B01L3/56 ,  B01L2200/0684 ,  B01L2300/045 ,  B04B5/0414

摘要： Compositions and methods for separating a sample of whole blood into a substantially non-activated platelet rich plasma fraction (PRP fraction) and at least one other fraction are provided. A sample of whole blood can be centrifuged in a collection tube comprising a separator substance formulated to settle between the PRP fraction and the at least one other fraction. Preferably, centrifugation is completed without substantial activation of platelets. Optionally, the separator substance could be hardened to form a solid barrier that allows removal of all or substantially all of the platelets in the PRP fraction without remixing of the PRP fraction with the at least one other fraction.

公开(公告)号：EP2227271B1

公开(公告)日：2018-01-24

申请号：EP08857318.3

申请日：2008-12-08

申请人： Miltenyi Biotec GmbH

发明人： MILTENYI, Stefan ,  SCHIMMELPFENNIG, Winfried ,  LANTOW, Holger ,  NEUSCHÄFER, Elmar, Niklas ,  BIEHL, Martin ,  KABAHA, Eiad ,  SCHULZ, Jürgen

IPC分类号： A61M1/02 ,  A61M1/36 ,  B04B13/00 ,  B03C1/032 ,  B03C1/033 ,  B03C1/034

CPC分类号： G01N33/58 ,  A61M1/0209 ,  A61M1/3618 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0071 ,  A61M2202/0413 ,  A61M2202/0427 ,  A61M2202/10 ,  B01D15/3809 ,  B01D15/3885 ,  B01D21/26 ,  B03C1/002 ,  B03C1/027 ,  B03C1/032 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/034 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  B04B1/12 ,  B04B5/00 ,  B04B5/04 ,  B04B5/0442 ,  B04B5/10 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/0464 ,  B04B2013/006 ,  C12M23/28 ,  C12M33/10 ,  C12M41/48 ,  C12M47/04 ,  C12N5/0636 ,  C12N5/0646 ,  C12N5/0647 ,  C12N5/0669 ,  G01N35/0098 ,  G01N2333/70596

摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

公开(公告)号：EP2835140B1

公开(公告)日：2017-11-08

申请号：EP13767918.9

申请日：2013-02-25

申请人： Terumo Kabushiki Kaisha

发明人： KIMURA Shigeyuki ,  KATAOKA Ryoji

IPC分类号： A61M1/02 ,  A61M1/38 ,  B04B5/04 ,  F16J15/34 ,  B04B7/08

CPC分类号： A61M1/3693 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/3696 ,  A61M1/382 ,  A61M2202/0427 ,  A61M2205/33 ,  A61M2205/331 ,  A61M2205/42 ,  B04B11/04 ,  B04B13/00

公开(公告)号：EP3108907A4

公开(公告)日：2017-10-25

申请号：EP15752439

申请日：2015-02-19

申请人： TORAY INDUSTRIES

发明人： NOSAKA SHIRO ,  UENO YOSHIYUKI ,  OSABE MASAHIRO ,  KISHIKAWA TATSUYA

IPC分类号： A61M1/02 ,  B01D63/02 ,  B01D69/08 ,  B01D71/68

CPC分类号： A61M1/0281 ,  A61M2202/0427 ,  B01D63/02 ,  B01D2315/08 ,  B01D2325/02 ,  B01D2325/04 ,  B01D2325/36

摘要： The present invention aims to provide a hollow fiber membrane module capable of producing washed platelets having a low total protein amount and a high total platelet count from a platelet suspension. The present invention provides a hollow fiber membrane module for washing platelets by removal of impurities from a platelet suspension, comprising: a housing having a platelet suspension inlet, washed platelet outlet, and filtrate outlet; and a hollow fiber membrane for filtering the platelet suspension, wherein pores through which the platelets do not pass, while the impurities pass, are formed, which hollow fiber membrane is arranged inside the housing; wherein the capacity of the inlet-side space which communicates with the platelet suspension inlet and stores the platelet suspension before being filtered through the hollow fiber membrane in the housing is 30 to 400 mL, and the module water permeability is 50 to 300 mL/Pa/hr.