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1.发明授权METHODS FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 有权合成方法阻碍构象肽PEPTIDOMETIKA及其作为合成疫苗
公开(公告)号：EP1629002B1
公开(公告)日：2009-01-07
申请号：EP04739532.2
申请日：2004-06-02
IPC分类号： C07K7/56 , C07K1/04 , C07K16/20 , A61K38/12 , A61K39/015
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S,4S)-4-functionalized proline residue. The invention further relates to the use of (2S,4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
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2.发明公开COMPOSITIONS AND METHODS FOR THE GENERATION OF PROTECTIVE IMMUNE RESPONSE AGAINST MALARIA 有权方法和组合物形成保护性免疫反应恶性疟原虫
公开(公告)号：EP1599225A2
公开(公告)日：2005-11-30
申请号：EP04716571.7
申请日：2004-03-03
发明人： PLUSCHKE, Gerd , MÜLLER, Markus , ROBINSON, John , ZURBRIGGEN, Rinaldo , FREUND-RENARD, Annabelle
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/55555 , A61K2039/6018 , Y02A50/412
摘要： The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.
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3.发明授权COMPOSITIONS AND METHODS FOR THE GENERATION OF PROTECTIVE IMMUNE RESPONSE AGAINST MALARIA 有权方法和组合物形成保护性免疫反应恶性疟原虫
公开(公告)号：EP1599225B1
公开(公告)日：2007-05-16
申请号：EP04716571.7
申请日：2004-03-03
发明人： PLUSCHKE, Gerd , MÜLLER, Markus , ROBINSON, John , ZURBRIGGEN, Rinaldo , FREUND-RENARD, Annabelle
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/55555 , A61K2039/6018 , Y02A50/412
摘要： The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.
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4.发明公开METHODS FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 有权合成方法阻碍构象肽PEPTIDOMETIKA及其作为合成疫苗
公开(公告)号：EP1629002A1
公开(公告)日：2006-03-01
申请号：EP04739532.2
申请日：2004-06-02
IPC分类号： C07K7/56 , C07K1/04 , C07K16/20 , A61K38/12 , A61K39/015
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S,4S)-4-functionalized proline residue. The invention further relates to the use of (2S,4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
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