公开(公告)号：EP4441069A1

公开(公告)日：2024-10-09

申请号：EP22844394.1

申请日：2022-12-02

Applicant: Bristol-Myers Squibb Company

Inventor： QIAO, Jennifer X. ,  POSS, Michael A. ,  ALLEN, Martin, Patrick ,  MAPELLI, Claudio ,  QUESNELLE, Claude, A. ,  TORTOLANI, David, R. ,  WANG, Tammy, C. ,  WANG, Tao ,  ZHANG, Yong ,  ZHANG, Yunhui ,  ZHANG, Zhongxing

IPC: C07K7/56 ,  A61P35/00 ,  A61P31/00 ,  A61P37/04 ,  C07D513/14 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K7/56 ,  A61P35/00 ,  A61K38/00 ,  A61P31/00 ,  A61P37/04

公开(公告)号：EP2603600B1

公开(公告)日：2018-11-21

申请号：EP11817162.8

申请日：2011-08-13

Applicant: Aileron Therapeutics, Inc.

Inventor： GUERLAVAIS, Vincent ,  KAWAHATA, Noriyuki

IPC: C12P21/06

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/56 ,  C07K14/4746

Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.

公开(公告)号：EP3383421A1

公开(公告)日：2018-10-10

申请号：EP16870001.1

申请日：2016-12-01

Applicant: The University of Hong Kong

Inventor： LI, Xuechen ,  LEE, Chi Lung ,  XU, Jianchao

IPC: A61K38/16 ,  C07K14/00

CPC classification number: C07K1/1075 ,  A61K38/00 ,  C07K1/122 ,  C07K7/56 ,  C07K7/64 ,  C07K14/001

Abstract: The present disclosure relates to the design and generation of stapled helical peptides that perturb protein-protein interactions (PPIs). The methods disclosed herein for preparing stapled peptides involve providing a peptide having a first amino acid that is functionalized with a salicylaldehyde ester side group and a second amino acid functionalized with a 1,2-hydroxyl amine side group; reacting the first and second amino acids to generate an N,O-benzylidene acetal moiety; and performing acidolysis of the resultant N,O-benzylidene acetal moiety to generate the stapled peptide. In many forms, the stapled helical peptides described herein are not hydrophobic.

公开(公告)号：EP3349779A1

公开(公告)日：2018-07-25

申请号：EP16766922.5

申请日：2016-09-14

Applicant: APEPTICO Forschung und Entwicklung GmbH

Inventor： WILLAM, Anita ,  LEMMENS-GRUBER, Rosa ,  TZOTZOS, Susan, Jane ,  FISCHER, Bernhard ,  SHABBIR, Waheed ,  LUCAS, Rudolf

IPC: A61K38/12 ,  C07K7/56 ,  C07K7/60 ,  A61P5/40

CPC classification number: A61K38/12 ,  C07K7/08 ,  C07K7/56 ,  C07K7/64

Abstract: A cyclic polypeptide comprising at least six contiguous amino acids from the amino acid sequence SEQ ID NO:1 Gly-Gln-Arg-Glu-Thr-Pro-Glu-Gly-Ala-Glu-Ala-Lys-Pro-Trp-Tyr for the treatment of autosomal recessive pseudohypoaldosteronism type 1 (PHA type 1B) or for the restoration of the Na+ transport capacity of mutated loss-of-function ENaC.

公开(公告)号：EP2832743B1

公开(公告)日：2018-07-18

申请号：EP13767887.6

申请日：2013-03-29

Applicant: Shanghai Techwell Biopharmaceutical Co., Ltd

Inventor： LIU, Shidong ,  ZHANG, Zhaoli ,  WANG, Xiusheng ,  ZHANG, Xiao ,  TANG, Zhijun ,  JI, Xiaoming

IPC: C07K7/56 ,  C07K1/14 ,  A61K38/12 ,  A61P31/10

CPC classification number: C07K7/56 ,  A61K38/00

Abstract: A high purity cyclopeptide crystal has a structure shown by Formula I. R represents H or a cation forming a pharmaceutically acceptable salt. Also disclosed are a preparation method and a use of the high-purity cyclopeptide crystal.

公开(公告)号：EP3294753A1

公开(公告)日：2018-03-21

申请号：EP16726798

申请日：2016-05-10

Applicant: JANSSEN VACCINES & PREVENTION BV

Inventor： VAN DONGEN MARIA ,  BUYCK CHRISTOPHE FRANCIS ROBERT NESTOR ,  SCHEPENS WIM BERT GRIET ,  JURASZEK JAROSLAW ,  KESTELEYN BART RUDOLF ROMANIE ,  RABOISSON PIERRE JEAN MARIE BERNARD ,  BRANDENBURG BOERRIES

IPC: C07K7/56 ,  A61K38/12 ,  A61P31/16

CPC classification number: C07K7/56 ,  A61K38/00 ,  C07K7/06 ,  C12N2760/16111 ,  G01N33/56983

Abstract: The present invention relates to novel peptidomimetic compounds that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses of phylogenetic group 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.

公开(公告)号：EP2807183B1

公开(公告)日：2018-02-28

申请号：EP13711953.3

申请日：2013-01-25

Applicant: Novartis AG

Inventor： GOLOSOV, Andrei ,  GROSCHE, Philipp ,  HU, Qi-Ying ,  IMASE, Hidetomo ,  PARKER, David, Thomas ,  YASOSHIMA, Kayo ,  ZECRI, Frederic ,  ZHAO, Hongjuan

IPC: C07K7/56 ,  C07K14/47 ,  A61K38/12

CPC classification number: A61M16/0816 ,  A61K38/00 ,  A61K38/10 ,  A61M16/0066 ,  A61M16/201 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2205/35 ,  A61M2205/502 ,  C07K7/08 ,  C07K7/56 ,  C07K7/60

Abstract: A pressure support system that comprises a patient circuit, a docking assembly, and a tank. The patient circuit delivers a pressurized flow of breathable gas to a patient. The docking assembly has an inlet and an outlet that is adapted to receive the pressurized flow of breathable gas, and is also adapted to be connected with the patient circuit. The tank is constructed and arranged to be removably connected with the docking assembly, and enables the pressurized flow of breathable gas to pass therethrough. The tank is also adapted to contain a liquid such that a humidity level of the pressurized flow of breathable gas is elevated as the pressurized flow of breathable gas passes therethrough.

公开(公告)号：EP2925772B1

公开(公告)日：2018-02-07

申请号：EP13812290.8

申请日：2013-12-03

Applicant: Novobiotic Pharmaceuticals, LLC

Inventor： PEOPLES, Aaron, J. ,  HUGHES, Dallas ,  LING, Losee, Lucy ,  MILLETT, William ,  NITTI, Anthony ,  SPOERING, Amy ,  STEADMAN, Victoria, Alexandra ,  CHIVA, Jean-Yves, Christophe ,  LAZARIDES, Linos ,  JONES, Michael, Kenyon ,  POULLENNEC, Karine, Gaelle ,  LEWIS, Kim ,  EPSTEIN, Slava

IPC: C07K11/02

CPC classification number: C07K7/56 ,  A61K38/00 ,  A61K38/15 ,  C07K11/02 ,  C12P17/14 ,  C12P21/02 ,  C12R1/01 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/421 ,  Y02A50/423 ,  Y02A50/473 ,  Y02A50/478 ,  Y02A50/479 ,  Y02A50/481 ,  Y02A50/491

Abstract: The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.

公开(公告)号：EP2764140B1

公开(公告)日：2017-08-30

申请号：EP12778672.1

申请日：2012-10-08

Applicant: Bicycle Therapeutics Limited

Inventor： TITE, John ,  WALKER, Edward ,  STACE, Catherine ,  TEUFEL, Daniel

IPC: C07K1/00

CPC classification number: C07K7/56 ,  A61K38/10 ,  A61K38/12 ,  C07K1/00 ,  C07K1/1075 ,  C07K2/00 ,  C07K7/08

Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.

Abstract translation: 本发明描述了对人血浆激肽释放酶特异性的肽配体。

公开(公告)号：EP2564862B1

公开(公告)日：2017-08-02

申请号：EP12174832.1

申请日：2008-02-25

Applicant: Aileron Therapeutics, Inc.

Inventor： Nash, Huw

IPC: C07C271/22

CPC classification number: C07K7/06 ,  C07C271/22 ,  C07C2603/18 ,  C07K1/006 ,  C07K1/1075 ,  C07K1/113 ,  C07K4/00 ,  C07K7/08 ,  C07K7/56 ,  C07K14/001 ,  C07K14/4748

Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.

Abstract translation: 本发明提供了新的拟肽大环化合物及其制备和使用方法，以及氨基酸类似物和形成大环的连接子，以及可用于其生产的试剂盒。