公开(公告)号：EP3134404A1

公开(公告)日：2017-03-01

申请号：EP15726685.9

申请日：2015-04-09

申请人： Pfizer Inc.

发明人： GRAY, David Lawrence Firman ,  ZHANG, Lei ,  BRODNEY, Michael Aaron ,  GREEN, Michael Eric ,  SUBRAMANYAM, Chakrapani

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P25/00

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D471/04

摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1 -associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.

公开(公告)号：EP3421462A1

公开(公告)日：2019-01-02

申请号：EP18180416.2

申请日：2014-06-13

申请人： Pfizer Inc.

发明人： BRODNEY, Michael Aaron ,  DAVOREN, Jennifer Elizabeth ,  DOUNAY, Amy Beth ,  EFREMOV, Ivan Viktorovich ,  GRAY, David Lawrence Firman ,  GREEN, Michael Eric ,  HENDERSON, Jaclyn Louise ,  LEE, Chewah ,  MENTE, Scot Richard ,  O'NEIL, Steven Victor ,  ROGERS, Bruce Nelsen ,  ZHANG, Lei

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D401/12 ,  A61K31/513 ,  A61K31/501 ,  A61K31/497 ,  A61P25/00 ,  A61K31/444 ,  A61K31/506

摘要： The present invention provides, in part, compounds of Formula I:

and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), age-related cognitive decline, dementia, and Parkinson's disease.

公开(公告)号：EP3052495A1

公开(公告)日：2016-08-10

申请号：EP14793620.7

申请日：2014-09-22

申请人： Pfizer Inc.

发明人： PETTERSSON, Martin Youngjin ,  JOHNSON, Douglas Scott ,  SUBRAMANYAM, Chakrapani ,  O'DONNELL, Christopher John ,  AM ENDE, Christopher William ,  GREEN, Michael Eric ,  PATEL, Nandini Chaturbhai ,  STIFF, Cory Michael ,  TRAN, Tuan Phong ,  KAUFFMAN, Gregory Wayne ,  STEPAN, Antonia Friederike ,  VERHOEST, Patrick Robert

IPC分类号： C07D471/04 ,  C07D498/04 ,  A61K31/498 ,  A61P25/00

CPC分类号： C07D471/04 ,  C07D498/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：EP2917195B1

公开(公告)日：2017-12-13

申请号：EP13821520.7

申请日：2013-10-22

申请人： Pfizer Inc.

发明人： DIRICO, Kenneth John ,  EUSTAQUIO, Alessandra S. ,  GREEN, Michael Eric ,  HE, Haiyin ,  HE, Min ,  KOEHN, Frank Erich ,  O'DONNELL, Christopher John ,  PUTHENVEETIL, Sujiet ,  RATNAYAKE, Anokha Sayani ,  SUBRAMANYAM, Chakrapani ,  TESKE, Jesse Alexander ,  YANG, Hui Yu

IPC分类号： C07D309/10 ,  C07D405/12 ,  C07D493/20 ,  A61K31/35 ,  A61P35/00

CPC分类号： A61K47/6855 ,  A61K31/35 ,  A61K31/351 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/496 ,  A61K31/501 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6869 ,  A61K47/6889 ,  C07D309/10 ,  C07D309/14 ,  C07D405/12 ,  C07D405/14 ,  C07D493/10 ,  C07D493/20

摘要： The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.

公开(公告)号：EP2897956A1

公开(公告)日：2015-07-29

申请号：EP13792085.6

申请日：2013-09-06

申请人： Pfizer Inc.

发明人： AM ENDE, Christopher William ,  GREEN, Michael Eric ,  JOHNSON, Douglas Scott ,  KAUFFMAN, Gregory Wayne ,  O'DONNELL, Christopher John ,  PATEL, Nandini Chaturbhai ,  PETTERSSON, Martin Youngjin ,  STEPAN, Antonia Friederike ,  STIFF, Cory Michael ,  SUBRAMANYAM, Chakrapani ,  TRAN, Tuan Phong ,  VERHOEST, Patrick Robert

IPC分类号： C07D471/04 ,  A61K31/4985 ,  A61P25/28

CPC分类号： C07D471/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：EP3137469A1

公开(公告)日：2017-03-08

申请号：EP15726691.7

申请日：2015-04-14

申请人： Pfizer Inc.

发明人： BRODNEY, Michael Aaron ,  DAVOREN, Jennifer Elizabeth ,  EFREMOV, Ivan Viktorovich ,  GRAY, David Lawrence Firman ,  GREEN, Michael Eric ,  O'NEIL, Steven Victor ,  ROGERS, Bruce Nelsen ,  ZHANG, Lei

IPC分类号： C07D487/04 ,  C07D491/048 ,  A61K31/4355 ,  A61P25/00

CPC分类号： C07D491/048 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

摘要： The present invention provides, in part, compounds of Formula (I): and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1 -associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), schizotypal personality disorder, cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, Parkinson's disease, anxiety, and depression.

摘要翻译： 本发明部分提供式（I）的化合物及其药学上可接受的盐; 制备过程; 中间体用于制备; 以及含有这些化合物或盐的组合物及其用于治疗D1介导的（或D1相关）疾病的用途，包括例如精神分裂症（例如其认知和阴性症状），分裂型人格障碍，认知障碍（例如，认知障碍相关 精神分裂症，AD，PD或药物治疗），ADHD，帕金森病，焦虑和抑郁。

公开(公告)号：EP2897956B1

公开(公告)日：2016-11-09

申请号：EP13792085.6

申请日：2013-09-06

申请人： Pfizer Inc.

发明人： AM ENDE, Christopher William ,  GREEN, Michael Eric ,  JOHNSON, Douglas Scott ,  KAUFFMAN, Gregory Wayne ,  O'DONNELL, Christopher John ,  PATEL, Nandini Chaturbhai ,  PETTERSSON, Martin Youngjin ,  STEPAN, Antonia Friederike ,  STIFF, Cory Michael ,  SUBRAMANYAM, Chakrapani ,  TRAN, Tuan Phong ,  VERHOEST, Patrick Robert

IPC分类号： C07D471/04 ,  A61K31/4985 ,  A61P25/28

CPC分类号： C07D471/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：EP3013813A1

公开(公告)日：2016-05-04

申请号：EP14739554.5

申请日：2014-06-13

申请人： Pfizer Inc.

发明人： BRODNEY, Michael Aaron ,  DAVOREN, Jennifer Elizabeth ,  DOUNAY, Amy Beth ,  EFREMOV, Ivan Viktorovich ,  GRAY, David Lawrence Firman ,  GREEN, Michael Eric ,  HENDERSON, Jaclyn Louise ,  LEE, Chewah ,  MENTE, Scot Richard ,  O'NEIL, Steven Victor ,  ROGERS, Bruce Nelsen ,  ZHANG, Lei

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D401/12 ,  A61K31/513 ,  A61K31/501 ,  A61K31/497 ,  A61P25/00

CPC分类号： C07D401/14 ,  A61K31/444 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14

摘要： The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), age-related cognitive decline, dementia, and Parkinson's disease.

摘要翻译： 及其药学上可接受的盐; 制备过程; 中间体用于制备; 以及含有这些化合物或盐的组合物及其用于治疗D1介导的（或D1相关）疾病的用途，包括例如精神分裂症（例如其认知和负面症状），认知障碍（例如，与精神分裂症相关的认知障碍，AD ，PD或药物治疗），ADHD，冲动性，强迫性赌博，暴饮暴食，自闭症谱系障碍，MCl，年龄相关认知衰退，痴呆，RLS，帕金森病，亨廷顿舞蹈病，焦虑症，抑郁症，MDD，TRD，双相情感障碍， 慢性冷漠，慢性疲劳，创伤后应激障碍，季节性情绪障碍，社会焦虑症，产后抑郁症，血清素综合征，药物滥用和毒品依赖，药物滥用复发，Tourette综合征，迟发性运动障碍，嗜睡，白天过度 嗜睡，恶病质，注意力不集中，性功能障碍，偏头痛，SLE，高血糖症，动脉粥样硬化，血脂异常，肥胖，糖尿病，败血症，缺血后小管 坏死，肾衰竭，低钠血症，抗性水肿，发作性睡病，高血压，充血性心力衰竭，术后眼睛低血压，睡眠障碍和疼痛。

公开(公告)号：EP2691393A1

公开(公告)日：2014-02-05

申请号：EP12713360.1

申请日：2012-03-21

申请人： Pfizer Inc.

发明人： AM ENDE, Christopher William ,  FISH, Benjamin Adam ,  GREEN, Michael Eric ,  JOHNSON, Douglas Scott ,  MULLINS, Patrick Bradley ,  O'DONNELL, Christopher John ,  PETTERSSON, Martin Youngjin ,  STIFF, Cory Michael ,  SUBRAMANYAM, Chakrapani ,  TRAN, Tuan Phong ,  NAVARATNAM, Thayalan

IPC分类号： C07D471/04 ,  A61K31/4985 ,  A61P25/00

CPC分类号： C07D471/04 ,  A61K31/4985 ,  A61K31/695 ,  A61K45/06 ,  C07D401/04 ,  C07D491/048 ,  C07F7/0812

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：EP3137469B1

公开(公告)日：2019-10-09

申请号：EP15726691.7

申请日：2015-04-14

申请人： Pfizer Inc.

发明人： BRODNEY, Michael Aaron ,  DAVOREN, Jennifer Elizabeth ,  EFREMOV, Ivan Viktorovich ,  GRAY, David Lawrence Firman ,  GREEN, Michael Eric ,  O'NEIL, Steven Victor ,  ROGERS, Bruce Nelsen ,  ZHANG, Lei

IPC分类号： C07D487/04 ,  C07D491/048 ,  A61K31/4355 ,  A61P25/00