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1.发明公开METHOXY-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF 审中-公开甲氧基取代的RORC2的吡咯并吡啶调节剂及其使用方法
公开(公告)号：EP3250570A1
公开(公告)日：2017-12-06
申请号：EP16703858.7
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： SCHNUTE, Mark Edward , FLICK, Andrew Christopher , JONES, Peter , KAILA, Neelu , MENTE, Scot Richard , TRZUPEK, John David , VAZQUEZ, Michael L. , XING, Li , ZHANG, Liying , WENNERSTAL, Goran Mattias , ZAMARATSKI, Edouard
IPC分类号： C07D471/04 , A61K31/435 , A61P29/02 , A61P37/08
CPC分类号： C07D471/04
摘要： The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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2.发明公开SULFONAMIDE-SUBSITUTED INDOLE MODULATORS OF RORC2 AND METHODS OF USE THEREOF 审中-公开RORC2的磺酰胺 - 取代吲哚调节剂及其使用方法
公开(公告)号：EP3250561A1
公开(公告)日：2017-12-06
申请号：EP16705819.7
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： SCHNUTE, Mark Edward , FLICK, Andrew Christopher , JONES, Peter , KAILA, Neelu , MENTE, Scot Richard , TRZUPEK, John David , VAZQUEZ, Michael L. , XING, Li , ZHANG, Liying , WENNERSTAL, Goran Mattias , ZAMARATSKI, Edouard
IPC分类号： C07D401/04 , A61K31/4439 , A61P17/06 , C07D401/14 , C07D405/14 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.
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