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1.发明公开BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS 审中-公开BICYCLISCHE-KONDENSIERTE HETEROARYL- ODER ARYLVERBINDUNGEN UND DEREN VERWENDUNG ALS IRAK4-INHIBITOREN
公开(公告)号：EP3126330A1
公开(公告)日：2017-02-08
申请号：EP15717250.3
申请日：2015-03-26
申请人： Pfizer Inc.
发明人： ANDERSON, David Randolph , BUNNAGE, Mark Edward , CURRAN, Kevin Joseph , DEHNHARDT, Christoph Martin , GAVRIN, Lori Krim , GOLDBERG, Joel Adam , HAN, Seungil , HEPWORTH, David , HUANG, Horng-Chih , LEE, Arthur , LEE, Katherine Lin , LOVERING, Frank Eldridge , LOWE, Michael Dennis , MATHIAS, John Paul , PAPAIOANNOU, Nikolaos , PATNY, Akshay , PIERCE, Betsy Susan , SAIAH, Eddine , STROHBACH, Joseph Walter , TRZUPEK, John David , VARGAS, Richard , WANG, Xiaolun , WRIGHT, Stephen Wayne , ZAPF, Christoph Wolfgang
IPC分类号： C07D207/26 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12
CPC分类号： C07D491/056 , A61K31/40 , A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K45/06 , C07C69/94 , C07D207/08 , C07D207/26 , C07D207/267 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07F7/1804
摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译： 公开了化合物的化合物，互变异构体和药学上可接受的盐，其中化合物具有如说明书中定义的式Ia结构。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。
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2.发明授权PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES AS INHIBITORS OF JANUS KINASES (JAK) 有权作为JANUS KINASES（JAK）抑制剂的吡咯并[2,3-d]嘧啶衍生物
公开(公告)号：EP2958921B1
公开(公告)日：2017-09-20
申请号：EP14705887.9
申请日：2014-02-11
申请人： Pfizer Inc.
发明人： BROWN, Matthew Frank , FENWICK, Ashley Edward , FLANAGAN, Mark Edward , GONZALES, Andrea , JOHNSON, Timothy Allan , KAILA, Neelu , MITTON-FRY, Mark J. , STROHBACH, Joseph Walter , TENBRINK, Ruth E. , TRZUPEK, John David , UNWALLA, Rayomand Jal , VAZQUEZ, Michael L. , PARIKH, Mihir, D.
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , A61P37/00
CPC分类号： A61K31/519 , A61K31/5386 , C07D207/18 , C07D487/04 , C07D519/00
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3.发明公开COMBINATION OF PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES WITH ONE OR MORE ADDITIONAL AGENTS AS INHIBITORS OF JANUS- RELATED KINASES (JAK) 审中-公开吡咯并[2,3-d]嘧啶衍生物与一种或多种附加药物作为JANUS-相关激酶抑制剂（JAK）的组合
公开(公告)号：EP3290421A1
公开(公告)日：2018-03-07
申请号：EP17191163.9
申请日：2014-02-11
申请人： Pfizer Inc.
发明人： BROWN, Matthew Frank , FENWICK, Ashley Edward , FLANAGAN, Mark Edward , GONZALES, Andrea , JOHNSON, Timothy Allan , KAILA, Neelu , MITTON-FRY, Mark J. , STROHBACH, Joseph Walter , TENBRINK, Ruth E. , TRZUPEK, John David , UNWALLA, Rayomand Jal , VAZQUEZ, Michael L. , PARIKH, Mihir, D.
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , A61P37/00
CPC分类号： A61K31/519 , A61K31/5386 , C07D207/18 , C07D487/04 , C07D519/00
摘要： Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
摘要翻译： 本文描述了吡咯并（2,3-d）嘧啶衍生物，它们作为Janus激酶（JAK）抑制剂的用途以及包含它们的药物组合物。
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公开(公告)号：EP3126330B1
公开(公告)日：2019-02-27
申请号：EP15717250.3
申请日：2015-03-26
申请人： Pfizer Inc.
发明人： ANDERSON, David Randolph , BUNNAGE, Mark Edward , CURRAN, Kevin Joseph , DEHNHARDT, Christoph Martin , GAVRIN, Lori Krim , GOLDBERG, Joel Adam , HAN, Seungil , HEPWORTH, David , HUANG, Horng-Chih , LEE, Arthur , LEE, Katherine Lin , LOVERING, Frank Eldridge , LOWE, Michael Dennis , MATHIAS, John Paul , PAPAIOANNOU, Nikolaos , PATNY, Akshay , PIERCE, Betsy Susan , SAIAH, Eddine , STROHBACH, Joseph Walter , TRZUPEK, John David , VARGAS, Richard , WANG, Xiaolun , WRIGHT, Stephen Wayne , ZAPF, Christoph Wolfgang
IPC分类号： C07D207/26 , C07D207/273 , C07D209/52 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D239/86 , C07D239/88 , C07D263/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12
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5.发明公开METHOXY-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF 审中-公开甲氧基取代的RORC2的吡咯并吡啶调节剂及其使用方法
公开(公告)号：EP3250570A1
公开(公告)日：2017-12-06
申请号：EP16703858.7
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： SCHNUTE, Mark Edward , FLICK, Andrew Christopher , JONES, Peter , KAILA, Neelu , MENTE, Scot Richard , TRZUPEK, John David , VAZQUEZ, Michael L. , XING, Li , ZHANG, Liying , WENNERSTAL, Goran Mattias , ZAMARATSKI, Edouard
IPC分类号： C07D471/04 , A61K31/435 , A61P29/02 , A61P37/08
CPC分类号： C07D471/04
摘要： The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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6.发明公开METHYL-AND TRIFLUOROMETHYL-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF 审中-公开甲基 - 和三氟甲基取代的吡咯并吡啶调节剂RORC2及其使用方法
公开(公告)号：EP3197882A1
公开(公告)日：2017-08-02
申请号：EP15778744.1
申请日：2015-09-22
申请人： Pfizer Inc.
发明人： FLICK, Andrew Christopher , JONES, Peter , KAILA, Neelu , MENTE, Scot Richard , SCHNUTE, Mark Edward , TRZUPEK, John David , VAZQUEZ, Michael L. , XING, Li , ZHANG, Liying , WENNERSTÅL, Göran Mattias , ZAMARATSKI, Edouard
IPC分类号： C07D401/14 , A61K31/454 , A61P29/02 , A61P37/08
CPC分类号： C07D471/04 , C07D401/14
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
摘要翻译： 本发明提供甲基 - 和三氟甲基 - 取代的吡咯并吡啶类化合物，其药物组合物，调节受试者中RORγ活性和/或减少IL-17的量的方法，以及使用此类吡咯并吡啶及其药物组合物治疗各种医学病症的方法。
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公开(公告)号：EP3858825A1
公开(公告)日：2021-08-04
申请号：EP21157042.9
申请日：2016-08-16
申请人： Pfizer Inc.
发明人： LEE, Katherine Lin , ALLAIS, Christophe Philippe , DEHNHARDT, Christoph Martin , GAVRIN, Lori Krim , HAN, Seungil , HEPWORTH, David , LEE, Arthur , LOVERING, Frank Eldridge , MATHIAS, John Paul , OWEN, Dafydd Rhys , PAPAIOANNOU, Nikolaos , SAIAH, Eddine , STROHBACH, Joseph Walter , TRZUPEK, John David , WRIGHT, Stephen Wayne , ZAPF, Christoph Wolfgang
IPC分类号： C07D401/12 , C07D413/14 , C07D401/14 , C07D491/18 , C07D471/04 , A61K31/4709 , A61K31/4725 , A61K31/4375 , C07D207/273 , A61P29/00 , A61P11/00 , A61P35/00 , A61P25/00
摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula IIc to IIi, IIl to IIv or IIx as defined in the claims. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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公开(公告)号：EP3536685A1
公开(公告)日：2019-09-11
申请号：EP19157789.9
申请日：2015-03-26
申请人： Pfizer Inc.
发明人： ANDERSON, David Randolph , BUNNAGE, Mark Edward , CURRAN, Kevin Joseph , DEHNHARDT, Christoph Martin , GAVRIN, Lori Krim , GOLDBERG, Joel Adam , HAN, Seungil , HEPWORTH, David , HUANG, Horng-Chih , LEE, Arthur , LEE, Katherine Lin , LOVERING, Frank Eldridge , LOWE, Michael Dennis , MATHIAS, John Paul , PAPAIOANNOU, Nikolaos , PATNY, Akshay , PIERCE, Betsy Susan , SAIAH, Eddine , STROHBACH, Joseph Walter , TRZUPEK, John David , VARGAS, Richard , WANG, Xiaolun , WRIGHT, Stephen Wayne , ZAPF, Christoph Wolfgang
IPC分类号： C07D207/26
摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia ,
as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed.-
公开(公告)号：EP3290421B1
公开(公告)日：2019-01-02
申请号：EP17191163.9
申请日：2014-02-11
申请人： Pfizer Inc.
发明人： BROWN, Matthew Frank , FENWICK, Ashley Edward , FLANAGAN, Mark Edward , GONZALES, Andrea , JOHNSON, Timothy Allan , KAILA, Neelu , MITTON-FRY, Mark J. , STROHBACH, Joseph Walter , TENBRINK, Ruth E. , TRZUPEK, John David , UNWALLA, Rayomand Jal , VAZQUEZ, Michael L. , PARIKH, Mihir, D.
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , A61P37/00
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公开(公告)号：EP3341367A1
公开(公告)日：2018-07-04
申请号：EP16762869.2
申请日：2016-08-16
申请人： Pfizer Inc.
发明人： LEE, Katherine Lin , ALLAIS, Christophe Philippe , DEHNHARDT, Christoph Martin , GAVRIN, Lori Krim , HAN, Seungil , HEPWORTH, David , LEE, Arthur , LOVERING, Frank Eldridge , MATHIAS, John Paul , OWEN, Dafydd Rhys , PAPAIOANNOU, Nikolaos , SAIAH, Eddine , STROHBACH, Joseph Walter , TRZUPEK, John David , WRIGHT, Stephen Wayne , ZAPF, Christoph Wolfgang
IPC分类号： C07D401/12 , C07D413/14 , C07D401/14 , C07D491/18 , C07D471/04 , A61K31/4709 , A61K31/4725 , A61K31/4375 , C07D207/273 , A61P29/00 , A61P11/00 , A61P35/00 , A61P25/00
CPC分类号： C07D401/12 , A61K31/4015 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/4745 , A61K45/06 , C07D207/273 , C07D401/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/18
摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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