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1.发明授权3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS 有权3-（4-氨基吡咯-2-基）甲基）-2-吲哚啉衍生物ALS蛋白激酶抑制剂
公开(公告)号：EP1370554B1
公开(公告)日：2005-10-19
申请号：EP02714897.2
申请日：2002-02-15
发明人： GUAN, Huiping , LIANG, Congxin , SUN, Li , TANG, Peng, Cho , WEI, Chung, Chen , MAURAGIS, Michael, A. , VOJKOVSKY, Tomas , JIN, Qingwu , HERRINTON, Paul, Matthew
IPC分类号： C07D403/06 , C07D403/14 , C07D471/04 , A61K31/404 , A61K31/4166 , A61K31/437 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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2.发明授权
公开(公告)号：EP1670785B1
公开(公告)日：2010-07-07
申请号：EP04769435.1
申请日：2004-09-20
发明人： BLASKO, Andrei , JIN, Qingwu , LU, Qun , MAURAGIS, Michael, Anthony Pfizer Global R & D , SONG, Dian , VONDERWELL, Brenda, Sue Pfizer Global R & D
IPC分类号： C07D403/06 , A61K31/404 , A61P35/00
CPC分类号： C07D403/06
摘要： The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H--indol-3-ylidene)methyl]-N-[(2)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3--yarboxamide,shown in structural formula (1) such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3--ylidene)methyl]-N-[(2S)-2-hyd carboxamide salts, and meth roxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3- ds of treating disorders such as cancer using such compositions.
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3.发明公开
公开(公告)号：EP1670785A1
公开(公告)日：2006-06-21
申请号：EP04769435.1
申请日：2004-09-20
发明人： BLASKO, Andrei , JIN, Qingwu , LU, Qun , MAURAGIS, Michael, Anthony Pfizer Global R & D , SONG, Dian , VONDERWELL, Brenda, Sue Pfizer Global R & D
IPC分类号： C07D403/06 , A61K31/404 , A61P35/00
CPC分类号： C07D403/06
摘要： The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H--indol-3-ylidene)methyl]-N-[(2)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3--yarboxamide,shown in structural formula (1) such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3--ylidene)methyl]-N-[(2S)-2-hyd carboxamide salts, and meth roxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3- ds of treating disorders such as cancer using such compositions.
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4.发明公开3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS 有权3-（4- AMIDOPYRROL -2-基亚甲基）-2-二氢吲哚酮衍生物ALS蛋白激酶抑制剂
公开(公告)号：EP1370554A1
公开(公告)日：2003-12-17
申请号：EP02714897.2
申请日：2002-02-15
发明人： GUAN, Huiping , LIANG, Congxin , SUN, Li , TANG, Peng, Cho , WEI, Chung, Chen , MAURAGIS, Michael, A. , VOJKOVSKY, Tomas , JIN, Qingwu , HERRINTON, Paul, Matthew
IPC分类号： C07D403/06 , C07D403/14 , C07D471/04 , A61K31/404 , A61K31/4166 , A61K31/437 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D403/06 , C07D403/14 , C07D471/04
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
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