专利检索 ap:("Pharmacia Corporation") AND inv:"CZYZEWSKI, Ann, M." 第 1 页

1.

发明授权
S-[2-[(1-IMINOETHYL)AMINO]ETHYL]-2-METHYL-L-CYSTEINE MALEATE HYDROCHLORIDE CRYSTALLINE SALT 有权
标题翻译： S- [2 - [（I-IMINOETHYL）氨基]乙基] -2-甲基-L-胞嘧啶 - 马来酸 - 羟基氯化钠晶体沉淀

公开(公告)号：EP1603872B1

公开(公告)日：2011-05-18

申请号：EP04717188.9

申请日：2004-03-04

申请人： Pharmacia Corporation

发明人： SHEIKH, Ahmad , BROSTROM, Lyle, R. , CZYZEWSKI, Ann, M. , ZIA, Vahid

IPC分类号： C07C323/59 , A61K31/198 , A61P29/00 , C07C319/28

CPC分类号： C07C323/59 , C07B2200/07 , C07B2200/13 , C07C319/28

摘要： A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl] -2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1 Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly packed agglomerates, which are particularly useful in making pharmaceutical compositions. Such pharmaceutical compositions are also described, as well as methods to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, and methods of treating conditions characterized by an overexpression on nitric oxide from the inducible isoform of nitric oxide synthase using the S-[2-[(1Iminoethyl)amino]ethyl] -2-methyl-L-cysteine maleate hydrochloride.

2.

发明公开
S-[2-[(1-IMINOETHYL)AMINO]ETHYL]-2-METHYL-L-CYSTEINE MALEATE HYDROCHLORIDE CRYSTALLINE SALT 有权
标题翻译： S- [2 - [（I-亚氨基乙基）氨基]乙基] -2-甲基-L-半胱氨酸马来酸盐的结晶盐酸盐

公开(公告)号：EP1603872A1

公开(公告)日：2005-12-14

申请号：EP04717188.9

申请日：2004-03-04

申请人： Pharmacia Corporation

发明人： SHEIKH, Ahmad , BROSTROM, Lyle, R. , CZYZEWSKI, Ann, M. , ZIA, Vahid

IPC分类号： C07C323/59 , A61K31/198 , A61P29/00 , C07C319/28

CPC分类号： C07C323/59 , C07B2200/07 , C07B2200/13 , C07C319/28

摘要： A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl] -2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1 Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly packed agglomerates, which are particularly useful in making pharmaceutical compositions. Such pharmaceutical compositions are also described, as well as methods to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, and methods of treating conditions characterized by an overexpression on nitric oxide from the inducible isoform of nitric oxide synthase using the S-[2-[(1Iminoethyl)amino]ethyl] -2-methyl-L-cysteine maleate hydrochloride.