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1.发明公开S-[2-[(1-IMINOETHYL)AMINO]ETHYL]-2-METHYL-L-CYSTEINE MALEATE HYDROCHLORIDE CRYSTALLINE SALT 有权S- [2 - [（I-亚氨基乙基）氨基]乙基] -2-甲基-L-半胱氨酸马来酸盐的结晶盐酸盐
公开(公告)号：EP1603872A1
公开(公告)日：2005-12-14
申请号：EP04717188.9
申请日：2004-03-04
IPC分类号： C07C323/59 , A61K31/198 , A61P29/00 , C07C319/28
CPC分类号： C07C323/59 , C07B2200/07 , C07B2200/13 , C07C319/28
摘要： A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl] -2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1 Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly packed agglomerates, which are particularly useful in making pharmaceutical compositions. Such pharmaceutical compositions are also described, as well as methods to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, and methods of treating conditions characterized by an overexpression on nitric oxide from the inducible isoform of nitric oxide synthase using the S-[2-[(1Iminoethyl)amino]ethyl] -2-methyl-L-cysteine maleate hydrochloride.
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2.发明授权S-[2-[(1-IMINOETHYL)AMINO]ETHYL]-2-METHYL-L-CYSTEINE MALEATE HYDROCHLORIDE CRYSTALLINE SALT 有权S- [2 - [（I-IMINOETHYL）氨基]乙基] -2-甲基-L-胞嘧啶 - 马来酸 - 羟基氯化钠晶体沉淀
公开(公告)号：EP1603872B1
公开(公告)日：2011-05-18
申请号：EP04717188.9
申请日：2004-03-04
IPC分类号： C07C323/59 , A61K31/198 , A61P29/00 , C07C319/28
CPC分类号： C07C323/59 , C07B2200/07 , C07B2200/13 , C07C319/28
摘要： A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl] -2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1 Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly packed agglomerates, which are particularly useful in making pharmaceutical compositions. Such pharmaceutical compositions are also described, as well as methods to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, and methods of treating conditions characterized by an overexpression on nitric oxide from the inducible isoform of nitric oxide synthase using the S-[2-[(1Iminoethyl)amino]ethyl] -2-methyl-L-cysteine maleate hydrochloride.
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3.发明公开S- 2- (1-IMINOETHYL)AMINO ETHYL -2-METHYL-L-C YSTEINE MALEATE FORM II CRYSTALLINE SALT 审中-公开结晶马来酸盐S- 2-（1-亚氨基乙基）氨基乙基-2-甲基-L-半胱氨酸的II
公开(公告)号：EP1603869A1
公开(公告)日：2005-12-14
申请号：EP04717175.6
申请日：2004-03-04
发明人： SHEIKH, Ahmad , BROSTROM, Lyle
IPC分类号： C07C323/58 , A61K31/155 , A61P29/00
CPC分类号： C07C323/58 , C07B2200/13
摘要： Form II crystalline maleate salt of S-[2-[(1-Iminoethyl)amino]ethyl] -2-methyl-L-cysteine is disclosed. The Form II crystalline salt is a channel hydrate, with a melting point of about 77.69 °C.
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