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1.发明公开HEXAHYDRO-7-IMINO-1H-AZEPIN-2-YL-HEXANOIC ACID DERIVATIVES AS INHIBITORS OF INDUCIBLE NITRIC OXIDE SYNTHASE 审中-公开六氢-7-亚氨基-1H-氮杂-2-基 - 己酸衍生物可诱导一氧化氮合酶的抑制剂
公开(公告)号：EP1305293A1
公开(公告)日：2003-05-02
申请号：EP01959537.0
申请日：2001-08-01
发明人： HANSEN, Donald, W. , TRIVEDI, Mahima , SNYDER, Jeffrey, S. , MOORMANN, Alan, E. , AWASTHI, Alok, K. , WEBBER, Ronald, Keith , FRANCZYK, Thaddeus, S.
IPC分类号： C07D233/12 , C07D223/10 , C07D498/04 , A61K31/55 , A61P29/00
CPC分类号： C07D223/12 , C07D223/10
摘要： Iminoazepinyl Hexanoic Acid derivatives of formula (I) as well as pharmaceutically acceptable salts and derivatives thereof useful in the inhibition of the inducible isoform of nitric oxide synthase for the treatment of arthritis, osteoarthritis, rheumatism, inflammation are disclosed.
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2.发明授权
公开(公告)号：EP1265860B1
公开(公告)日：2005-05-18
申请号：EP01922636.4
申请日：2001-03-23
发明人： WEBBER, Ronald, Keith , AWASTHI, Alok, K. , BERGMANIS, Arija, A. , DURLEY, Richard, C. , GANSER, Scott, S. , HAGEN, Timothy, J. , HALLINAN, Ann, E. , HANSEN, Donald, W. , HICKORY, Brian, S. , MOORMANN, Alan, E. , PITZELE, Barnett, S. , PROMO, Michelle, A. , SCHARTMAN, Richard, R. , SNYDER, Jeffrey, S. , TRIVEDI, Mahima , TSYMBALOV, Sofya , PHILLIPS, W. Gary, , Vonder Embse, Richard , Yalamanchili, Gopichand
IPC分类号： C07C323/58 , A61K31/155 , A61P29/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to S-[2-(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.
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3.发明公开2-AMINO-2-ALKYL-3 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开2-氨基-2-烷基-3-庚烯酸HEPTYNSÄURE及其衍生物作为抑制剂一氧化氮合酶
公开(公告)号：EP1317417A2
公开(公告)日：2003-06-11
申请号：EP01968865.4
申请日：2001-09-15
发明人： HANSEN, Donald, Jr. , WEBBER, Ronald, Keith , PITZELE, Barnett, S. , AWASTHI, Alok, K. , SIKORSKI, James , TRIVEDI, Mahima , MOORMAN, Alan, E.
IPC分类号： C07C251/08 , C07C229/30 , C07C271/22 , C07C255/30 , A61K31/201 , A61P19/02
CPC分类号： C07C255/30 , C07B2200/07 , C07B2200/09 , C07C229/22 , C07C229/26 , C07C257/14 , C07C271/22
摘要： The present invention relates to 2-amino-2-alkyl-3 heptenoic and heptynoic as derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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4.发明公开
公开(公告)号：EP1265860A1
公开(公告)日：2002-12-18
申请号：EP01922636.4
申请日：2001-03-23
发明人： WEBBER, Ronald, Keith , AWASTHI, Alok, K. , BERGMANIS, Arija, A. , DURLEY, Richard, C. , GANSER, Scott, S. , HAGEN, Timothy, J. , HALLINAN, Ann, E. , HANSEN, Donald, W. , HICKORY, Brian, S. , MOORMANN, Alan, E. , PITZELE, Barnett, S. , PROMO, Michelle, A. , SCHARTMAN, Richard, R. , SNYDER, Jeffrey, S. , TRIVEDI, Mahima , TSYMBALOV, Sofya , PHILLIPS, Gary, W., , Vonder Embse, Richard , Yalamanchili, Gopichand
IPC分类号： C07C323/58 , A61K31/155 , A61P29/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to S-[2-(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.
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5.发明授权2-AMINO-2-ALKYL-5 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 有权2-氨基-2-烷基-5-庚烯酸HEPTYNSÄURE及其衍生物氧化氮合酶的抑制剂
公开(公告)号：EP1317421B1
公开(公告)日：2005-02-23
申请号：EP01970937.7
申请日：2001-09-15
发明人： HANSEN, Donald, Jr. , WEBBER, Ronald, Keith , PITZELE, Barnett, S. , SIKORSKI, James , MASSA, Mark, A. , HAGEN, Timothy, J. , GRAPPERHAUS, Margaret , WANG, Lijuan, Jane , BERGMANIS, Arija, A. , KRAMER, Steven, W. , HALLINAN, E., Ann
IPC分类号： C07C257/14 , C07C271/22 , C07C229/30 , C07D271/06
CPC分类号： C07D271/07 , C07B2200/07 , C07B2200/09 , C07C229/30 , C07C257/14 , C07C259/14 , C07C271/22 , C07D413/06 , C07F7/1856
摘要： The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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6.发明公开2-AMINO-2-ALKYL-4 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开2-氨基-2-烷基-4-己烯酸HEXYNSÄURE及其衍生物作为抑制剂一氧化氮合酶
公开(公告)号：EP1317416A2
公开(公告)日：2003-06-11
申请号：EP01968875.3
申请日：2001-09-15
发明人： DURLEY, Richard, C. , SIKORSKI, James , HANSEN, Donald, Jr. , PROMO, Michelle, A. , WEBBER, Ronald, Keith , PITZELE, Barnett, S. , AWASTHI, Alok, K. , MOORMAN, Alan, E.
IPC分类号： C07C251/00
CPC分类号： C07D209/48 , A61K31/198 , C07C229/30 , C07C251/08 , C07C251/16 , C07C255/30 , C07C257/14 , C07C271/22 , C07D271/07 , C07D413/06
摘要： The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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7.发明公开HALOGENATED 2-AMINO-4, 5 HEPTENOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开卤化2-氨基-4-庚烯酸衍生物作为一氧化氮合酶的抑制剂
公开(公告)号：EP1272455A1
公开(公告)日：2003-01-08
申请号：EP01927026.3
申请日：2001-04-13
发明人： HANSEN, Donald, W., Jr. , WEBBER, Ronald, Keith , AWASTHI, Alok, K. , MANNING, Pamela, T. , SIKORSKI, James, A.
IPC分类号： C07C241/00 , C07C243/00 , C07C249/00 , C07C251/00 , C07C259/00 , C07C273/00 , C07C275/00 , C07C277/00 , C07C279/00 , C07C291/00 , C07C229/00 , A01N47/10
CPC分类号： C07C257/14
摘要： The present invention contains halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
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8.发明公开2-AMINO-2-ALKYL-5 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 有权2-氨基-2-烷基-5-庚烯酸HEPTYNSÄURE及其衍生物氧化氮合酶的抑制剂
公开(公告)号：EP1317421A1
公开(公告)日：2003-06-11
申请号：EP01970937.7
申请日：2001-09-15
发明人： HANSEN, Donald, Jr. , WEBBER, Ronald, Keith , PITZELE, Barnett, S. , SIKORSKI, James , MASSA, Mark, A. , HAGEN, Timothy, J. , GRAPPERHAUS, Margaret , WANG, Lijuan, Jane , BERGMANIS, Arija, A. , KRAMER, Steven, W. , HALLINAN, E., Ann
IPC分类号： C07C257/14 , C07C271/22 , C07C229/30 , C07D271/06
CPC分类号： C07D271/07 , C07B2200/07 , C07B2200/09 , C07C229/30 , C07C257/14 , C07C259/14 , C07C271/22 , C07D413/06 , C07F7/1856
摘要： The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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9.发明公开2-AMINO-2-ALKYL-3 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开2-氨基-2-烷基-3-HEXENSÄURE-HEXYNSÄUREDERIVATE和作为抑制剂一氧化氮合酶
公开(公告)号：EP1317420A1
公开(公告)日：2003-06-11
申请号：EP01970857.7
申请日：2001-09-15
IPC分类号： C07C257/14 , C07C271/22 , C07C255/30 , C07C229/30
CPC分类号： C07C255/30 , C07B2200/07 , C07B2200/09 , C07C229/30 , C07C257/14 , C07C271/22
摘要： The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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10.发明公开2-AMINO-2-ALKYL-4 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开2-氨基-2-烷基-4-庚烯酸HEPTYNSÄURE及其衍生物作为抑制剂一氧化氮合酶
公开(公告)号：EP1317418A2
公开(公告)日：2003-06-11
申请号：EP01968866.2
申请日：2001-09-15
发明人： HANSEN, Donald, Jr. , TRIVEDI, Mahima , TOTH, Mihaly, V. , WEBBER, Ronald, Keith , PITZELE, Barnett, S. , AWASTHI, Alok, K. , SIKORSKI, James , MOORMAN, Alan, E.
IPC分类号： C07C251/24 , C07C229/30 , C07C271/22 , C07D271/07 , C07D263/38 , C07C251/08 , A61K31/201 , A61P19/02
CPC分类号： C07D271/07 , C07B2200/07 , C07B2200/09 , C07C229/30 , C07C257/14 , C07C271/22 , C07D263/38 , C07F7/1852
摘要： The present invention relates to 2-amino-2-alkyl-4 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
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