公开(公告)号：EP1530565A1

公开(公告)日：2005-05-18

申请号：EP03765851.5

申请日：2003-07-18

申请人： Pharmacia Corporation

发明人： HAGEN, Timothy, J. ,  WEIER, Richard, M. ,  XU, Xiangdong ,  HOUDEK, Stephen, C. ,  CLARE, Michael

IPC分类号： C07D333/50 ,  C07D333/80 ,  A61P29/00

CPC分类号： C07D333/80 ,  C07D333/74

摘要： The present invention provides substituted thiophene carboxamide compounds having structural Formula I and isomers, tautomers, polymorphs, carriers, prodrugs, and pharmaceutically acceptable salts thereof, compositions comprising such, and methods for treating diseases associated with kinase activity. More specifically, the present invention provides methods of treatment of a variety of diseases associated with IKK2 including the treatment of inflammation, other inflammation-associated disorders, such as, as an analgesic in the treatment of pain and headaches, arthritis, including but not limited to rheumatoid arthritis, asthma, gastrointestinal conditions such as inflammatory bowel disease, vascular diseases, viral infections such as AIDS, and cancer.

公开(公告)号：EP1476431A1

公开(公告)日：2004-11-17

申请号：EP03742812.5

申请日：2003-02-19

申请人： Pharmacia Corporation

发明人： XU, Xiangdong ,  CLARE, Michael ,  LENNON, Patrick ,  METZ, Suzanne ,  VAZQUEZ, Michael ,  WEIER, Richard, M. ,  WOLFSON, Serge, G.

IPC分类号： C07D231/54 ,  C07D487/04 ,  C07D495/04 ,  A61K31/416 ,  A61P35/02

CPC分类号： C07D471/04 ,  C07D231/54 ,  C07D487/04 ,  C07D495/04

摘要： The present invention relates to substituted tricyclic pyrazole derivatives, compositions comprising such, intermediates, methods of making tricyclic pyrazole derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

公开(公告)号：EP1438293A2

公开(公告)日：2004-07-21

申请号：EP02778279.6

申请日：2002-09-19

申请人： Pharmacia Corporation

发明人： GENG, Lifeng ,  CLARE, Michael ,  HANSON, Gunnar, J. ,  HUANG, He ,  IULA, Donna M. ,  LIA0, Shuyuan ,  STEALEY, Michael, A. ,  METZ, Suzanne ,  VAZQUEZ, Michael, L. ,  WEIER, Richard, M.

IPC分类号： C07D231/56 ,  A61K31/415 ,  A61P29/00 ,  A61P43/00

CPC分类号： C07D231/56 ,  C07D231/54 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14

摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

公开(公告)号：EP1427706B1

公开(公告)日：2007-05-30

申请号：EP02763656.2

申请日：2002-09-19

申请人： Pharmacia Corporation

发明人： METZ, Suzanne ,  CLARE, Michael ,  CRICH, Joyce, Z. ,  HAGEN, Timothy, J. ,  HANSON, Gunnar, J. ,  HUANG, He ,  HOUDEK, Stephen, J. ,  STEALEY, Michael, A. ,  VAZQUEZ, Michael, L. ,  WEIER, Richard, M. ,  XU, Xiangdong

IPC分类号： C07D231/56 ,  C07D491/04 ,  C07D495/04 ,  C07D495/12 ,  C07D471/04 ,  A61K31/415 ,  A61K31/435

CPC分类号： C07D231/56 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14

摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

公开(公告)号：EP1427707A1

公开(公告)日：2004-06-16

申请号：EP02763657.0

申请日：2002-09-19

申请人： Pharmacia Corporation

发明人： STEALEY, Michael, A. ,  CLARE, Michael ,  CRICH, Joyce, Z. ,  HANAU, Cathleen, E. ,  KOSZYK, Francis, J. ,  PARTIS, Richard, A. ,  XU, Xiangdong ,  WEIER, Richard, M.

IPC分类号： C07D231/56 ,  A61K31/415 ,  A61P19/02 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D405/04 ,  C07D471/04

摘要： The present invention relates to substituted indazole derivatives, compositions comprising such, intermediates, methods of making substituted indazolel derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

公开(公告)号：EP1427706A1

公开(公告)日：2004-06-16

申请号：EP02763656.2

申请日：2002-09-19

申请人： Pharmacia Corporation

发明人： METZ, Suzanne ,  CLARE, Michael ,  CRICH, Joyce, Z. ,  HAGEN, Timothy, J. ,  HANSON, Gunnar, J. ,  HUANG, He ,  HOUDEK, Stephen, J. ,  STEALEY, Michael, A. ,  VAZQUEZ, Michael, L. ,  WEIER, Richard, M. ,  XU, Xiangdong

IPC分类号： C07D231/56 ,  C07D491/04 ,  C07D495/04 ,  C07D495/12 ,  C07D471/04 ,  A61K31/415 ,  A61K31/435

CPC分类号： C07D231/56 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14

摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.