公开(公告)号：EP2152708A1

公开(公告)日：2010-02-17

申请号：EP07797679.3

申请日：2007-05-23

申请人： Pharmacopeia, LLC

发明人： ROUGHTEN, Andrew ,  RONG, Yajing ,  HO, Koc Kan ,  OHLMEYER, Michael ,  DILLER, David

IPC分类号： C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  A61K31/522 ,  A61P37/06

CPC分类号： C07D471/04 ,  C07D473/00 ,  C07D473/32 ,  C07D487/04

摘要： A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKCΘ inhibitors, and their methods of use are disclosed. The genus is represented by the formula (I). A representative example is: (II).

摘要翻译： 公开了可用作PKCθ抑制剂的嘌呤酮和1H-咪唑并吡啶酮的化学属及其使用方法。 该属由式（I）表示。 一个代表性的例子是：（II）。

公开(公告)号：EP2294071A1

公开(公告)日：2011-03-16

申请号：EP09729779.0

申请日：2009-04-08

申请人： N.V. Organon ,  Pharmacopeia, LLC

发明人： ROUGHTON, Andrew Laird ,  HO, Koc-Kan ,  OHLMEYER, Michael ,  DILLER, David ,  NEAGU, Irina ,  KINGSBURY, Celia ,  CHAN, Jui-Hsiang ,  LOMMERSE, Johannes, Petrus, Maria ,  TEERHUIS, Neeltje, Miranda ,  WIJKMANS, Jacobus Cornelis Henricus Maria ,  PLATE, Ralf

IPC分类号： C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： The present invention relates to a pyrrolo[2,3-d]pyrimidin-2-yl-amine derivative according to formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said pyrrolo[2,3-d]pyrimidine-2-ylamine derivatives and to their use in therapy, for instance in the treatment of PKCθ mediated disorders.