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公开(公告)号：EP1802293A2
公开(公告)日：2007-07-04
申请号：EP05709127.4
申请日：2005-02-24
申请人： Pharmos Corporation
IPC分类号： A61K31/12 , A61K31/13 , A61K31/095 , A61K31/135 , A61K31/045 , C07C69/00 , C07C49/00 , C07C41/00
CPC分类号： A61K31/13
摘要： The present invention relates to orally effective ligands of the peripheral cannabinoid thereof, receptor CB2 especially (+)-α pinene derivatives, and to pharmaceutical compositions thereof, which are useful for prevention, alleviation or treatment of autoimmune neurodegenerative disorders, in particular multiple sclerosis and associated symptoms. Methods of the invention are useful when the active ingredient is administered alone or in combination with existing therapeutic modalities. The compositions are administered by oral route.
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公开(公告)号：EP2139852A1
公开(公告)日：2010-01-06
申请号：EP07849595.9
申请日：2007-12-19
申请人： Pharmos Corporation
IPC分类号： C07C311/39 , A61K31/18 , A61P29/00 , C07C311/40 , C07C311/48 , C07C311/51 , C07D207/48 , C07D209/08 , C07D213/42 , C07D213/74 , C07D217/02 , C07D231/38 , C07D239/52 , C07D295/12 , C07D307/14 , C07D307/52 , C07D309/04 , C07D317/58 , C07D319/18 , C07D405/12 , C07D471/08
CPC分类号： C07C311/39 , C07C311/40 , C07C311/48 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/48 , C07D213/38 , C07D213/42 , C07D217/04 , C07D231/38 , C07D295/12 , C07D295/13 , C07D295/22 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D405/12 , C07D471/08
摘要： The present invention relates to sulfonamide derivatives of formula (I) (wherein R1, R2, R3, R3', R4and R5are as defined in the claims), to pharmaceutical compositions comprising the same, and to uses thereof. Compounds of the invention have a common wide range of beneficial therapeutic indications. In particular, compounds of the invention are useful analgesic and anti-inflammatory agents.
摘要翻译： 本发明提供了本文定义的式（I）的磺酰胺化合物，含有其的药物组合物和使用这些化合物和药物组合物的治疗方法。 这些化合物具有普遍广泛的有益治疗适应症，特别是作为止痛剂和抗炎剂。
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公开(公告)号：EP1885709A2
公开(公告)日：2008-02-13
申请号：EP06756188.6
申请日：2006-05-31
申请人： Pharmos Corporation
发明人： YACOVAN, Avihai , GRYNSZPAN, Flavio , AIZIKOVICH, Alexander , BRODY, Marcus Stephen , BAR-JOSEPH, Avi , MEILIN, Sigal
IPC分类号： C07D307/91 , C07D307/93 , A61K31/343 , A61P25/00 , A61P37/02
CPC分类号： C07D307/91 , C07D307/93
摘要： The present invention relates to benzofuran derivatives , to pharmaceutical compositions comprising same, and to methods of usa thereof . Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of benef icial therapeutic indications . In particular, compounds or the invention are useful ae analgesic, neuroprotective, immunomodulatory and anfci - inf lammatory agents .
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