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1.发明公开PROSTATE CANCER-RELATED COMPOSITIONS, METHODS, AND KITS BASED ON DNA MACROARRAY PROTEOMICS PLATFORMS 有权在相关组合物，方法和药盒前列腺癌基因DNA上MACRO-ARRAY PROTEOME PLATFORMS
公开(公告)号：EP1507787A2
公开(公告)日：2005-02-23
申请号：EP03733941.3
申请日：2003-05-07
发明人： STEARNS, Mark , HU, Youji , WANG, Min
IPC分类号： C07H1/00 , C07H5/00 , C07H5/06 , C07H21/04 , C08B37/00 , A61K35/14 , A61K38/00 , C07K1/00 , C07K2/00 , C07K4/00
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4748 , C07K2319/20 , C07K2319/23 , C07K2319/40 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434
摘要： The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCADM-1 expression and/or production and activity of PCADM-1 polypeptide. Further, the invention relates to novel assays for the identification of DNA-binding proteins and the double-stranded oligonucleotide sequences that specifically bind with them. Finally, the invention relates to DNAZYMs or DNA enzymes which specifically bind PCADM-1 mRNA to inhibit PCADM-1 gene expression and thereby destroy tumor cells and tumor tissue.
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2.发明授权PROSTATE CANCER-RELATED COMPOSITIONS, METHODS, AND KITS BASED ON DNA MACROARRAY PROTEOMICS PLATFORMS 有权在相关组合物，方法和药盒前列腺癌基因DNA上MACRO-ARRAY PROTEOME PLATFORMS
公开(公告)号：EP1507787B1
公开(公告)日：2011-11-23
申请号：EP03733941.3
申请日：2003-05-07
发明人： STEARNS, Mark , HU, Youji , WANG, Min
IPC分类号： C07H1/00 , C07H5/00 , C07H5/06 , C07H21/04 , C08B37/00 , A61K35/14 , A61K38/00 , C07K1/00 , C07K2/00 , C07K4/00
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4748 , C07K2319/20 , C07K2319/23 , C07K2319/40 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57434
摘要： The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCADM-1 expression and/or production and activity of PCADM-1 polypeptide. Further, the invention relates to novel assays for the identification of DNA-binding proteins and the double-stranded oligonucleotide sequences that specifically bind with them. Finally, the invention relates to DNAZYMs or DNA enzymes which specifically bind PCADM-1 mRNA to inhibit PCADM-1 gene expression and thereby destroy tumor cells and tumor tissue.
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