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公开(公告)号：EP2864491B1
公开(公告)日：2018-10-17
申请号：EP13806939.8
申请日：2013-06-21
申请人： Phytogene, Inc.
发明人： BHUIYA, Mohammad Wadud , CHEN, Hui , CAI, Xianpeng , HAN, Jixiang , YU, Xiaodan
CPC分类号： C12P5/005 , C07K2319/00 , C12N9/88 , C12Q1/527 , C12Y401/01 , C12Y403/01005 , C12Y403/01024
摘要： The subject technology generally relates to biosynthesis of styrene. Certain embodiments of the subject technology is based, in part, on the recognition that phenylalanine can be converted to styrene by a two-step pathway of deamination and decarboxylation, with trans-cinnamic acid (tCA) as the intermediate. Two types of enzymes are directly involved in this process, phenylalanine ammonia lyase (PAL), which converts phenylalanine to tCA, and cinnamic acid decarboxylase, which coverts tCA to styrene. Host cells expressing these two types of enzymes can be cultured in bioreactor to produce styrene from renewable substrates such as glucose.
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公开(公告)号：EP2864491A2
公开(公告)日：2015-04-29
申请号：EP13806939.8
申请日：2013-06-21
申请人： Phytogene, Inc.
发明人： BHUIYA, Mohammad Wadud , CHEN, Hui , CAI, Xianpeng , HAN, Jixiang , YU, Xiaodan
CPC分类号： C12P5/005 , C07K2319/00 , C12N9/88 , C12Q1/527 , C12Y401/01 , C12Y403/01005 , C12Y403/01024
摘要： The subject technology generally relates to biosynthesis of styrene. Certain embodiments of the subject technology is based, in part, on the recognition that phenylalanine can be converted to styrene by a two-step pathway of deamination and de-carboxylation, with trans-cinnamic acid (tCA) as the intermediate. Two types of enzymes are directly involved in this process, phenylalanine ammonia lyase (PAL), which converts phenylalanine to tCA, and cinnamic acid decarboxylase, which coverts tCA to styrene. Host cells expressing these two types of enzymes can be cultured in bioreactor to produce styrene from renewable substrates such as glucose.
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