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    ENZYMES AND METHODS FOR STYRENE SYNTHESIS
    2.
    发明公开
    ENZYMES AND METHODS FOR STYRENE SYNTHESIS 审中-公开
    ENZYME UND VERFAHREN ZUR STYROLSYNTHESE

    公开(公告)号：EP2864491A4

    公开(公告)日：2016-05-11

    申请号：EP13806939

    申请日：2013-06-21

    申请人： PHYTOGENE INC

    发明人： BHUIYA MOHAMMAD WADUD ,  CHEN HUI ,  CAI XIANPENG ,  HAN JIXIANG ,  YU XIAODAN

    IPC分类号： C12P7/40 ,  C12N1/26 ,  C12N9/00 ,  C12N9/88 ,  C12N15/62 ,  C12P5/00 ,  C12P7/22

    CPC分类号： C12P5/005 ,  C07K2319/00 ,  C12N9/88 ,  C12Q1/527 ,  C12Y401/01 ,  C12Y403/01005 ,  C12Y403/01024

    摘要： The subject technology generally relates to biosynthesis of styrene. Certain embodiments of the subject technology is based, in part, on the recognition that phenylalanine can be converted to styrene by a two-step pathway of deamination and decarboxylation, with trans-cinnamic acid (tCA) as the intermediate. Two types of enzymes are directly involved in this process, phenylalanine ammonia lyase (PAL), which converts phenylalanine to tCA, and cinnamic acid decarboxylase, which coverts tCA to styrene. Host cells expressing these two types of enzymes can be cultured in bioreactor to produce styrene from renewable substrates such as glucose.

    摘要翻译： 主题技术一般涉及苯乙烯的生物合成。 本发明技术的某些实施方案部分地基于通过脱去和脱羧的两步途径将苯丙氨酸转化为苯乙烯的认识，以反式肉桂酸（tCA）为中间体。 两种类型的酶直接参与此过程，苯丙氨酸氨裂解酶（PAL），其将苯丙氨酸转化为tCA，肉桂酸脱羧酶将tCA覆盖到苯乙烯。 可以在生物反应器中培养表达这两种类型的酶的宿主细胞，以从诸如葡萄糖的可再生的底物生产苯乙烯。

    GENETICALLY MODIFIED PROBIOTIC FOR THE TREATMENT OF PHENYLKETONURIA (PKU) DISEASE
    6.
    发明公开
    GENETICALLY MODIFIED PROBIOTIC FOR THE TREATMENT OF PHENYLKETONURIA (PKU) DISEASE 审中-公开
    遗传修饰的益生菌治疗苯丙酮尿症（PKU）疾病

    公开(公告)号：EP3222288A1

    公开(公告)日：2017-09-27

    申请号：EP16194601.7

    申请日：2013-07-26

    申请人： University of North Texas

    发明人： Deming, Katherine ,  Allen, Michael ,  Von Herbing, Ione, Hunt

    IPC分类号： A61K38/51 ,  A61K48/00 ,  A61K35/741 ,  A61K35/747

    CPC分类号： A61K35/747 ,  A61K35/741 ,  A61K38/51 ,  A61K2035/115 ,  C12Y403/01024

    摘要： A GMP adapted to provide the PAL gene for the treatment of PKU when administered orally. The GMP of the present invention may include a probiotic, a PAL gene to be expressed using the probiotic, wherein the PAL gene is functionally attached to a promoter and a ribosome binding site, and may be codon-optimized for expression in a certain host organism. A method of treating the metabolic disease of PKU by oral administration and ingestion of a GMP is also provided.

    摘要翻译： 适用于口服给药时提供PAL基因治疗PKU的GMP。 本发明的GMP可以包括益生菌，使用益生菌表达的PAL基因，其中PAL基因在功能上与启动子和核糖体结合位点连接，并且可以进行密码子优化用于在某些宿主生物体中表达 。 还提供了通过口服和摄入GMP来治疗PKU的代谢性疾病的方法。

    BIOCHEMICAL STRESS RESISTANT MICROBIAL ORGANISM
    8.
    发明公开
    BIOCHEMICAL STRESS RESISTANT MICROBIAL ORGANISM 审中-公开
    生物化学家压力表MIKROBIELLER ORGANISMUS

    公开(公告)号：EP2904100A1

    公开(公告)日：2015-08-12

    申请号：EP13773256.6

    申请日：2013-10-04

    申请人： Biochemtex S.p.A.

    发明人： BRANDUARDI, Paola ,  PORRO, Danilo

    IPC分类号： C12N9/88 ,  C12P7/10

    CPC分类号： C12N9/88 ,  C12P7/10 ,  C12Y403/01003 ,  C12Y403/01023 ,  C12Y403/01024 ,  C12Y403/01025 ,  Y02E50/16

    摘要： It is disclosed a non-naturally occurring microbial organism comprising at least one exogenous nucleic acid encoding an enzyme, or a portion thereof, selected from the group of ammonia lyase. Preferably, the enzyme is PAL3, and the at least one exogenous nucleic acid is obtained from
    Arabidopsis thaliana . The non-naturally occurring microbial organism has an increased resistance to biochemical stress compared to the starting microbial organism, as induced for instance by oxidative stress or organic acid stress. Preferably, the non-naturally occurring microbial organism is a yeast and it may be used for fermenting a carbon source obtained from a ligno-cellulosic feedstock.

    摘要翻译： 公开了一种非天然存在的微生物生物体，其包含至少一种编码选自氨裂解酶的酶或其一部分的外源核酸。 优选地，酶是PAL3，并且所述至少一种外源核酸从拟南芥获得。 非天然存在的微生物生物体与起始的微生物有关，比如通过氧化应激或有机酸胁迫诱导，对生物化学应激的抵抗力增加。 优选地，非天然存在的微生物是酵母，并且可以用于发酵从木质纤维素原料获得的碳源。

    METHODS AND COMPOSITIONS FOR TREATING PHENYLKETONURIA
    9.
    发明公开
    METHODS AND COMPOSITIONS FOR TREATING PHENYLKETONURIA 有权
    治疗苯丙酮尿症的方法和组合物

    公开(公告)号：EP2170314A1

    公开(公告)日：2010-04-07

    申请号：EP08754714.7

    申请日：2008-05-23

    申请人： The Board of Regents of The University of Texas System

    发明人： MATALON, Reuben

    IPC分类号： A61K31/195 ,  C12N9/00

    CPC分类号： C12N9/0071 ,  A61K38/00 ,  A61K38/48 ,  C12N9/88 ,  C12Y114/16001 ,  C12Y403/01024 ,  A61K2300/00

    摘要： Provided herein are methods for treating a subject suffering from phenylketonuria by administering a phenylalanine hydroxylase ('PAH') and/or a phenylalanine ammonia lyase ('PAL') to the subject under conditions effective to deliver the phenylalanine 4-hydroxylase and/or PAL to the subject's small intestine. Also provided are methods for increasing the therapeutic activity of a phenylalanine 4-hydroxylase by thiolating the phenylalanine 4-hydroxylase. In addition, provided are oral dosage forms that include a phenylalanine 4-hydroxylase and/or a PAL and an enteric coating.

    摘要翻译： 本文提供了通过在有效递送苯丙氨酸4-羟化酶和/或PAL的条件下向受试者施用苯丙氨酸羟化酶（'PAH'）和/或苯丙氨酸氨裂解酶（'PAL'）来治疗患有苯丙酮尿症的受试者的方法 到受试者的小肠。 还提供了通过硫化苯丙氨酸4-羟化酶来提高苯丙氨酸4-羟化酶的治疗活性的方法。 另外，提供了包含苯丙氨酸4-羟化酶和/或PAL和肠溶衣的口服剂型。