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1.发明授权
公开(公告)号：EP2321323B1
公开(公告)日：2013-05-29
申请号：EP09802516.6
申请日：2009-07-29
申请人： Pierre Fabre Medicament , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , FOURNIAL, Anaïs , MORDANT, Céline , FAHY, Jacques
IPC分类号： C07D493/18 , A61K31/357 , A61P35/00
CPC分类号： C07D493/18 , C07D519/00
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2.发明公开
公开(公告)号：EP2235022A1
公开(公告)日：2010-10-06
申请号：EP08864687.2
申请日：2008-12-22
申请人： Pierre Fabre Medicament , Centre National de la Recherche Scientifique - CNRS , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , GRELLEPOIS, Fabienne , CHOLLET, Constance , FAHY, Jacques , MORDANT, Céline
IPC分类号： C07D493/18 , A61K31/35 , A61K31/357
CPC分类号： C07D519/00 , C07F9/6561
摘要： The present invention relates to dimeric derivatives of 10-trifluoromethylated artemisinin of formula (I) : or a pharmaceutically acceptable salt thereof with B1 and B2 selected from C=O, CHOH and CH2, as well as to their use in treating cancer and to their preparation method.
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3.发明授权
公开(公告)号：EP2235022B1
公开(公告)日：2015-08-05
申请号：EP08864687.2
申请日：2008-12-22
申请人： Pierre Fabre Médicament , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , GRELLEPOIS, Fabienne , CHOLLET, Constance , FAHY, Jacques , MORDANT, Céline
IPC分类号： C07D493/18 , A61K31/35 , A61K31/357
CPC分类号： C07D519/00 , C07F9/6561
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4.发明授权
公开(公告)号：EP2321323B9
公开(公告)日：2014-04-23
申请号：EP09802516.6
申请日：2009-07-29
申请人： Pierre Fabre Médicament , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , FOURNIAL, Anaïs , MORDANT, Céline , FAHY, Jacques
IPC分类号： C07D493/18 , A61K31/357 , A61P35/00
CPC分类号： C07D493/18 , C07D519/00
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5.发明公开
公开(公告)号：EP2321323A1
公开(公告)日：2011-05-18
申请号：EP09802516.6
申请日：2009-07-29
申请人： Pierre Fabre Medicament , Centre National de la Recherche Scientifique (C.N.R.S) , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , FOURNIAL, Anaïs , MORDANT, Céline , FAHY, Jacques
IPC分类号： C07D493/18 , A61K31/357 , A61P35/00
CPC分类号： C07D493/18 , C07D519/00
摘要： The present invention relates to dimeric derivatives of 10-trifluoromethylated artemisinin of formula (I) below: Formula (I) and the pharmaceutically acceptable salts thereof, and also to the preparation method thereof and to the uses thereof, especially in the treatment of cancer.
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