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公开(公告)号：EP2010202B1
公开(公告)日：2013-09-25
申请号：EP07735435.5
申请日：2007-04-10
发明人： MAHAJAN, Girish, Badrinath , GEORGE, Saji, David , RANADIVE, Prafull, Vasant , MISHRA, Prabhu Dutt, Satyanarayan , EYYAMMADICHIYIL, Sreekumar, Sankaranarayanan , PANSHIKAR, Rajan, Mukund , SAWANT, Satish, Namdeo , KRISHNA, Sridevi , SIVAKUMAR, Meenakshi , PARI, Koteppa , THOMAS, Becky, Mary , PATEL, Zarine, Eruch , VISHWAKARMA, Ram , NAIK, Chandrakant, Govind , D'SOUZA, Lisette , DEVI, Prabha
CPC分类号： A61K38/12 , C07K5/0821
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公开(公告)号：EP1639094A1
公开(公告)日：2006-03-29
申请号：EP03769746.3
申请日：2003-11-04
发明人： DEVI, Prabha , NAIK, Chandrakant, Govind , WAHIDULLA, Solimabi , D'SOUZA, Lisette , RODRIGUES, Ely , PEKETI, Asha
摘要： The present invention relates to a plant mangrove-associated fungus Culvularia lunata of International deposition no. MTCC 5109, and a simple and efficient method of obtaining high yield of pure mannitol from a plant mangrove-associated fungus Curvularia lunata, said method comprising steps of cutting the leaves into small pieces and placing it on potato dextrose agar (PDA) plates for 48 hours, maintaining the culture at temperature ranging between 26-470C and salinity ranging between 4-32 ppt with occasional stress conditions for about 17-19 days to obtain mycelial mat, sonicating the mat to lyse the cells, extracting crude from the sonicated mat using methanol repeatedly, concentrating the crude, treating the concentrated crude extract with solvents of increasing polarity, obtaining aqueous fraction as white powder residue after the treatment containing crude mannitol, purifying the crude mannitol by chromatography to obtain pure mannitol with about 75% of the total crude extract.
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公开(公告)号：EP2010202A2
公开(公告)日：2009-01-07
申请号：EP07735435.5
申请日：2007-04-10
发明人： MAHAJAN, Girish, Badrinath , GEORGE, Saji, David , RANADIVE, Prafull, Vasant , MISHRA, Prabhu Dutt, Satyanarayan , EYYAMMADICHIYIL, Sreekumar, Sankaranarayanan , PANSHIKAR, Rajan, Mukund , SAWANT, Satish, Namdeo , KRISHNA, Sridevi , SIVAKUMAR, Meenakshi , PARI, Koteppa , THOMAS, Becky, Mary , PATEL, Zarine, Eruch , VISHWAKARMA, Ram , NAIK, Chandrakant, Govind , D'SOUZA, Lisette , DEVI, Prabha
IPC分类号： A61K38/12
CPC分类号： A61K38/12 , C07K5/0821
摘要： This invention relates to a novel purified compound PM181104, of formula (I) of molecular weight 1514 and molecular formula C69H66N18O13S5; which is obtained by fermentation of the microorganism belonging to Kocuria species (ZMA B-1 / MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging to Kocuria species (ZMA B-1 / MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.
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