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公开(公告)号：EP1036083B9
公开(公告)日：2005-01-12
申请号：EP98946627.1
申请日：1998-10-13
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公开(公告)号：EP1181298B1
公开(公告)日：2006-07-19
申请号：EP00920937.0
申请日：2000-04-19
CPC分类号： C07H17/08
摘要： The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-O-methyl-erythromycin A of general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, wherein A stands for NH group and B simultaneously stands for C=O group, or A stands for C=O group and B simultaneously stands for NH group, and the radicals R , R , R , R , R , R have the meaning given in claim 1.
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3.发明公开Q-ALKYL MACROLIDE AND AZALIDE DERIVATIVES AND REGIOSELECTIVE PROCESS FOR THEIR PREPARATION 有权REGIO选择性工艺用于生产O-烷基大环内酯类阿扎利衍生物
公开(公告)号：EP1633764A1
公开(公告)日：2006-03-15
申请号：EP04735055.8
申请日：2004-05-27
摘要： The present disclooure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also relates to a process for the preparation of 11-O-alkyl macrolides and azalides by regioselective 11-O-alkylation of macrolides and azalides having a vicinal diol system, using diazoalkanes in the presence of transition-metal halides or boric acid as catalysts. In another aspect, the disclosure relates to uses of the 11 -0-alkyl macrolides and azalides as antibacterial agents or intermediates for the synthesis of other antibacterial agents.
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