公开(公告)号：EP3405476A1

公开(公告)日：2018-11-28

申请号：EP17741733.4

申请日：2017-01-20

申请人： Polypeptide Laboratories Holding (PPL) AB

发明人： FORNI, Luciano ,  CARBAJO LOPEZ, Daniel ,  ALBERICIO PALOMERA, Fernando

IPC分类号： C07K1/10 ,  C07K5/02 ,  C07K7/02

CPC分类号： C07K1/10 ,  C07K1/02 ,  C07K1/026 ,  C07K14/605

摘要： The invention discloses a method for the preparation of a peptide by liquid phase coupling of two fragments, an N-terminal fragment and a C-terminal fragment of the desired peptide, wherein the C-terminal fragment is protected on its C-terminal COOH by a psWang linker; the method is demonstrated with liraglutide wherein the C-terminal fragment carries the Palmitoyl-Glu-OtBu residue on the Lys.