专利检索 ap:("Polypeptide Laboratories Holding (PPL) AB") AND inv:"ALBERICIO PALOMERA, Fernando" 第 1 页

1.

发明公开
METHOD FOR THE PREPARATION OF H-ARG (MIS) -OH 审中-公开

公开(公告)号：EP3523278A1

公开(公告)日：2019-08-14

申请号：EP16918163.3

申请日：2016-10-09

申请人： Polypeptide Laboratories Holding (PPL) AB

发明人： TAN, Deyong , DAI, Joanna , GIRAUD, Matthieu , ALBERICIO PALOMERA, Fernando

IPC分类号： C07D209/30 , C07D209/56 , C07D209/70 , C07D209/32 , C07D209/34

2.

发明公开
METHOD FOR PREPARATION OF PEPTIDES WITH psWANG LINKER 审中-公开

公开(公告)号：EP3405476A1

公开(公告)日：2018-11-28

申请号：EP17741733.4

申请日：2017-01-20

申请人： Polypeptide Laboratories Holding (PPL) AB

发明人： FORNI, Luciano , CARBAJO LOPEZ, Daniel , ALBERICIO PALOMERA, Fernando

IPC分类号： C07K1/10 , C07K5/02 , C07K7/02

CPC分类号： C07K1/10 , C07K1/02 , C07K1/026 , C07K14/605

摘要： The invention discloses a method for the preparation of a peptide by liquid phase coupling of two fragments, an N-terminal fragment and a C-terminal fragment of the desired peptide, wherein the C-terminal fragment is protected on its C-terminal COOH by a psWang linker; the method is demonstrated with liraglutide wherein the C-terminal fragment carries the Palmitoyl-Glu-OtBu residue on the Lys.