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2.发明公开IMMUNOGENIC COMPOSITIONS COMPRISING SILICIFIED VIRUS AND METHODS OF USE 审中-公开WITH A硅化病毒AND METHOD免疫原性组合物使用
公开(公告)号：EP2950817A1
公开(公告)日：2015-12-09
申请号：EP14745410.2
申请日：2014-01-31
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/235 , A61K39/285 , A61K39/29 , A61K39/292 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55588 , C12N7/00 , C12N2710/10021 , C12N2710/10034 , C12N2710/24121 , C12N2710/24134 , C12N2720/12321 , C12N2720/12334 , C12N2740/16021 , C12N2740/16034 , C12N2760/16021 , C12N2760/16034 , C12N2770/20021 , C12N2770/20034 , C12N2770/24021 , C12N2770/24034 , C12N2770/24221 , C12N2770/24234 , C12N2770/32421 , C12N2770/32434 , C12N2770/32621 , C12N2770/32634 , C12N2795/10134 , C12N2795/14034 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/466
摘要： It is disclosed herein that viruses coated in silica retain infectivity and the capacity to induce an immune response in an infected host. In addition, silicified virus is remarkably resistant to desiccation. Provided herein are methods of inducing a virus-specific immune response in a subject by administering to the subject an effective amount of silicified virus or silicified virus particles. Methods of enhancing a virus-specific cell-mediated immune response (such as a T cell-mediated immune response) in a subject by administering to the subject a silicified virus or silicified virus particles are also described herein. Further provided are immunogenic compositions comprising silicified virus or silicified virus particles, such as compositions useful as vaccines. The immunogenic compositions include a pharmaceutically acceptable carrier and/or an adjuvant.
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公开(公告)号：EP2640842B1
公开(公告)日：2018-05-30
申请号：EP11841347.5
申请日：2011-11-17
申请人： Aduro Biotech, Inc. , Providence Health & Services-Oregon D/b/a Providence Portland Medical Center
发明人： LAUER, Peter, M. , BAHJAT, Keith
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/522 , A61K2039/523 , C07K14/71
摘要： The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a composition which expresses at least one immunogenic polypeptide, the amino acid sequence of which comprise a plurality of EGFRvIII polypeptide sequences, the sequence of which each comprise EEKKGNYV (SEQ ID NO: 3), and/or administering the polypeptide itself.
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4.发明公开
公开(公告)号：EP2640842A1
公开(公告)日：2013-09-25
申请号：EP11841347.5
申请日：2011-11-17
发明人： LAUER, Peter, M. , BAHJAT, Keith
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/522 , A61K2039/523 , C07K14/71
摘要： The present invention relates to methods of inducing a T-cell response against a EGFRvIII in a subject. These method comprise administering to a subject a composition which expresses at least one immunogenic polypeptide, the amino acid sequence of which comprise a plurality of EGFRvIII polypeptide sequences, the sequence of which each comprise EEKKGNYV (SEQ ID NO: 3), and/or administering the polypeptide itself.
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