公开(公告)号：EP3010522A1

公开(公告)日：2016-04-27

申请号：EP14801627.2

申请日：2014-05-21

申请人： President and Fellows of Harvard College

发明人： SUPER, Michael ,  WATTERS, Alexander L. ,  SNELL, Philip T. ,  INGBER, Donald E.

IPC分类号： A61K38/00 ,  C07K14/805

CPC分类号： C12N9/2474 ,  A61K38/00 ,  C07K14/805 ,  C12N9/96 ,  C12Y302/01035

摘要： Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of for example, sepsis and rhabdomyolysis.

公开(公告)号：EP3848044A1

公开(公告)日：2021-07-14

申请号：EP20213586.9

申请日：2014-05-21

申请人： President and Fellows of Harvard College

发明人： SUPER, Michael ,  WATTERS, Alexander L. ,  SNELL, Philip T. ,  INGBER, Donald E

IPC分类号： A61K38/00 ,  C07K14/805 ,  A61P21/00 ,  A61P31/00

摘要： Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.

公开(公告)号：EP3458483A1

公开(公告)日：2019-03-27

申请号：EP17729583.9

申请日：2017-05-16

申请人： President and Fellows of Harvard College

发明人： LESLIE, Daniel Christopher ,  DOYLE, Thomas ,  WATERHOUSE, Anna ,  RODAS, Melissa ,  WATTERS, Alexander L. ,  SUPER, Michael ,  INGBER, Donald E.

IPC分类号： C07K17/08

公开(公告)号：EP3848045A1

公开(公告)日：2021-07-14

申请号：EP21150097.0

申请日：2014-05-21

申请人： President and Fellows of Harvard College

发明人： SUPER, Michael ,  WATTERS, Alexander L. ,  SNELL, Philip T. ,  INGBER, Donald E.

IPC分类号： A61K38/00 ,  C07K14/805 ,  A61P21/00 ,  A61P31/00

摘要： Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.

公开(公告)号：EP3019207A2

公开(公告)日：2016-05-18

申请号：EP14852476.2

申请日：2014-07-10

申请人： President and Fellows of Harvard College

发明人： INGBER, Donald ,  LESLIE, Daniel C. ,  SUPER, Michael ,  WATTERS, Alexander L. ,  WATERHOUSE, Anna

IPC分类号： A61L29/08 ,  B05D5/08 ,  C09D5/00

CPC分类号： A61L31/08 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  B05D5/08 ,  B05D5/086 ,  C09D5/16

摘要： Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.

摘要翻译： 公开了制品的制造方法和用于改性表面的疏液性的用途。 排液表面包括包含锚定层的表面。 在表面上形成固定化分子锚定层的锚定层具有锚定分子，其中每个锚定分子具有与表面共价连接的头基和功能尾组。 锚定分子彼此交联以形成交联网络。 功能尾组对润滑液具有亲和性，润滑液被施加到被处理表面以形成润滑层。 锚定层和补充润滑液通过非共价吸引力保持在一起。 一起，这些层形成一个超疏水滑表面，排斥某些不混溶的液体，并防止其中所含组分的吸附，凝结和表面结垢。