公开(公告)号：EP3821818A3

公开(公告)日：2021-07-21

申请号：EP20199089.2

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B17/00 ,  A61B18/24 ,  A61F2/00 ,  A61B17/12 ,  A61B18/00 ,  A61B18/22

摘要： An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect ( e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.

公开(公告)号：EP3142586B1

公开(公告)日：2020-09-30

申请号：EP15792211.3

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute Of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B18/24 ,  A61B18/22 ,  A61B17/12 ,  A61M25/10 ,  A61M25/00 ,  A61B18/00 ,  A61B17/00

公开(公告)号：EP3142586A1

公开(公告)日：2017-03-22

申请号：EP15792211.3

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute Of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B18/22

摘要： An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.

摘要翻译： 一种可插入的光分配导管装置，包括一个包括近端和远端的轴，延伸穿过该轴的光导，以及可从该导管可移位地延伸到该镜容纳和反射从该光导发出的光的位置的镜。 镜子可以是充气气球上的涂层的形式; 并且当充气时，气囊可以将贴片压在缺陷（例如，心室脓肿缺损）上，同时光固化粘合剂，使贴片与具有缺陷的结构结合，从而补救缺陷。

公开(公告)号：EP3821818A2

公开(公告)日：2021-05-19

申请号：EP20199089.2

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B17/00 ,  A61B18/24 ,  A61F2/00 ,  A61B17/12 ,  A61B18/00 ,  A61B18/22

摘要： An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect ( e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.

公开(公告)号：EP3004221A1

公开(公告)日：2016-04-13

申请号：EP14732750.6

申请日：2014-05-23

申请人： Massachusetts Institute of Technology ,  The Children's Medical Center Corporation ,  The Brigham and Women's Hospital, Inc.

发明人： KARP, Jeffrey M. ,  DEL NIDO, Pedro ,  LANG, Nora ,  LANGER, Robert S. ,  PEREIRA, Maria Jose M.N. ,  LEE, Yuhan

IPC分类号： C08J3/24 ,  C08L67/06 ,  A61L24/04 ,  A61L15/22 ,  A61L15/58

CPC分类号： A61L24/046 ,  A61L15/26 ,  A61L15/42 ,  A61L15/58 ,  A61L24/001 ,  A61L2400/18 ,  C08F2222/1073 ,  C08G63/47 ,  C08G63/914 ,  C08L67/04

摘要： Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response.

摘要翻译： 提供用作组织密封剂和粘合剂的预聚物，及其制备和使用方法。 预聚物具有流动特性，使得它们可以通过注射器或导管施用，但足够粘稠以在施用部位保持就位，而不会从组织中流出。 预聚物也足够疏水以抵抗身体液体的冲洗。 预聚物在体液中是稳定的; 也就是预聚物在体液中不会自发交联，而不存在有意施加的刺激以引发交联。 交联时，粘合剂在存在血液和其他体液时显示出显着的粘合强度。 粘合剂具有足够的弹性，使得其能够抵抗下面的组织的运动。 粘合剂可以提供止血密封。 粘合剂是可生物降解和生物相容的，导致最小的炎症反应。

公开(公告)号：EP3416593A1

公开(公告)日：2018-12-26

申请号：EP17753844.4

申请日：2017-02-16

申请人： Children's Medical Center Corporation ,  The Brigham and Women's Hospital, Inc.

发明人： FEINS, Eric N. ,  DEL NIDO, Pedro J. ,  VASILYEV, Nikolay V. ,  YAMAUCHI, Haruo ,  PERRIN, Douglas P. ,  HAMMER, Peter ,  ARABAGI, Veaceslav ,  KARP, Jeffrey M. ,  LEE, Yuhan ,  O'CEARBHAILL, Eoin D.

IPC分类号： A61F2/28 ,  A61F2/24 ,  A61F2/00 ,  A61L27/50 ,  A61L27/58 ,  A61L27/14 ,  A61L27/04 ,  A61F2/30

CPC分类号： A61L27/58 ,  A61F2/2445 ,  A61F2/2846 ,  A61F2250/0007 ,  A61F2250/0082 ,  A61L27/04 ,  A61L27/14 ,  A61L27/50

摘要： An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the outer element.

公开(公告)号：EP3352738A1

公开(公告)日：2018-08-01

申请号：EP16849871.5

申请日：2016-09-26

申请人： The Brigham and Women's Hospital, Inc.

发明人： KARP, Jeffrey M. ,  LEE, Yuhan ,  TAVAKKOLI, Ali ,  DEELMAN, Tarawatie E.

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K31/715 ,  A61K31/737

CPC分类号： A61K31/737 ,  A61K9/0053 ,  A61K9/107 ,  A61K31/7024 ,  A61K31/721 ,  A61K47/36 ,  A61K47/38

摘要： This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.