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    SAMPLE PREPARATION DEVICES AND METHODS
    3.
    发明公开
    SAMPLE PREPARATION DEVICES AND METHODS 审中-公开
    PROBENAUFBEREITUNGSVORRICHTUNGEN UNDOVERHREN

    公开(公告)号：EP3149151A1

    公开(公告)日：2017-04-05

    申请号：EP15798802.3

    申请日：2015-05-29

    申请人： Pressure Biosciences, Inc.

    发明人： GROSS, Vera ,  TING, Edmund, Y. ,  LAZAREV, Alexander ,  SCHUMACHER, Richard, T.

    IPC分类号： C12N1/06 ,  C12M3/08 ,  G01N1/28

    CPC分类号： B01L3/50853 ,  B01L3/5082 ,  B01L2300/042 ,  B01L2300/046 ,  G01N1/286

    摘要： Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

    摘要翻译： 公开了通过压力循环技术进行样品制备的装置和方法。 用于样品制备的装置包括具有内表面，顶部和底部的管，所述管被配置为在底部容纳样品并被接收到用于样品制备的压力室中，所述管可拆卸地连接到 所述管和从所述盖延伸到所述管中的锥形细长构件，所述锥形细长构件构造成接触所述管的内表面和所述管的底部中的样品，其中所述管是可变形的，使得在压力下操作 管对锥形细长构件变形以促进样品的破坏。

    ULTRAHIGH PRESSURE COMPACT VALVE WITH THROTTLING CAPABILITY
    6.
    发明公开
    ULTRAHIGH PRESSURE COMPACT VALVE WITH THROTTLING CAPABILITY 审中-公开

    公开(公告)号：EP3347630A1

    公开(公告)日：2018-07-18

    申请号：EP16845029.4

    申请日：2016-09-08

    申请人： Pressure Biosciences, Inc.

    发明人： TING, Edmund, Y. ,  LAZAREV, Alexander ,  MA, Jun

    IPC分类号： F16K3/24 ,  F16K1/12 ,  F16K1/38 ,  F16K31/62

    CPC分类号： F16K1/12 ,  F16K1/14 ,  F16K1/38 ,  F16K3/24 ,  F16K31/62

    摘要： A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.

    FLOW-THROUGH HIGH HYDROSTATIC PRESSURE MICROFLUIDIC SAMPLE PREPARATION DEVICE AND RELATED METHODS THEREFOR
    7.
    发明公开
    FLOW-THROUGH HIGH HYDROSTATIC PRESSURE MICROFLUIDIC SAMPLE PREPARATION DEVICE AND RELATED METHODS THEREFOR 审中-公开
    器件及其制造微流体样品与高静压力流量与相关方法

    公开(公告)号：EP2608886A2

    公开(公告)日：2013-07-03

    申请号：EP11818797.0

    申请日：2011-08-18

    申请人： Pressure Biosciences, Inc. ,  Lazarev, Alexander

    发明人： LAZAREV, Alexander

    IPC分类号： B01L3/02

    CPC分类号： G01N1/286 ,  G01N35/1095 ,  Y10T436/25

    摘要： Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.