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1.发明公开
公开(公告)号：EP2890801A2
公开(公告)日：2015-07-08
申请号：EP13815583.3
申请日：2013-08-28
IPC分类号： C12P7/42
CPC分类号： C12P7/42
摘要： The present invention relates to a method for microbial fermentation and biotransformation of aromatic acids to aromatic acids with reduced carbon atoms of wide commercial importance using a culture of actinomycete species. Amycolatopsis sp or the mutant thereof is employed in the present invention to convert natural as well as synthetic aromatic acids to reduced carbon aromatic acids with wide applications. The said culture in the disclosed invention is adapted to grow at 37-46° C. to achieve the biotransformation of aromatic acid to reduced carbon aromatic acid is accomplished at 37-46° C. to obtain a higher yield of the product.
摘要翻译： 本发明涉及一种微生物发酵方法，使用放线菌种的培养将芳香酸生物转化为具有广泛商业重要性的具有降低的碳原子的芳族酸。 本发明中采用无菌纲或其突变体，将广泛应用的天然和合成芳香酸转化为还原性碳芳香酸。 所公开的发明中的所述培养物适于在37-46℃下生长以在37-46℃下实现芳族酸生物转化成还原性碳芳族酸，从而获得更高的产率。
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2.发明公开CONTINUOUS BIOTRANSFORMATION OF SUBSTITUTED AROMATIC CARBOXYLIC ACIDS TO THEIR SELECTIVE ALDEHYDES AND ALCOHOLS 审中-公开KONTINUIERLICHE BIOTRANSFORMATION SUBSTITUIERTER AROMATISCHERCARBONSÄURENZU SELEKTIVER ALDEHYDEN UND ALKOHOLEN
公开(公告)号：EP2890800A2
公开(公告)日：2015-07-08
申请号：EP13815584.1
申请日：2013-08-28
CPC分类号： C12P13/001 , C12P7/22 , C12P7/24 , C12R1/645 , Y02P20/582
摘要： The present invention discloses a novel method for biological reduction of the carboxylic acids to their corresponding aldehydes and/or alcohols with high productivity and high yield by using fungus in the category of basidiomycetes. This reduction is specific and selective for its functional group (—COOH), without affecting other functional group such as—R groups (—OH, —NH2, -alkyl, -alkyoxy) and their position, number on aromatic ring. The method of the invention relates to reduction of aryl acids to aldehyde and/or alcohols by employing a white rot fungus—Pycnoporus cinnabarinus, an organism of basidiomycete species, grown in vessel/column. The biotransformation was performed in vessel/column/fermentor with pH control, dissolved oxygen, membrane system, product extractor is attached.
摘要翻译： 本发明公开了通过使用担子菌类中的真菌，以高生产率和高产率将羧酸生物还原成其相应的醛和/或醇的新方法。 这种还原对于其官能团（-COOH）是特异性和选择性的，而不影响其它官能团如-R基（-OH，-NH 2， - 烷基， - 烷氧基）及其在芳环上的位置数。 本发明的方法涉及通过使用生长在容器/柱中的白腐霉真菌（Pycnoporus cinnabarinus），担子菌种的生物体将芳基酸还原成醛和/或醇。 生物转化在带有pH控制，溶解氧，膜系统，产品提取器的容器/柱/发酵罐中进行。
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