公开(公告)号：EP1885485A1

公开(公告)日：2008-02-13

申请号：EP06727050.4

申请日：2006-05-09

申请人： ProMetic BioSciences Limited

发明人： BETLEY, Jason, Richard ,  PEARSON, James Ch., ProMetic BioSciences Ltd. ,  KUHN, Claudia Hildegard, ProMetic BioSciences Ltd. ,  BAINES, Baldev Singh, ProMetic BioSciences Ltd.

IPC分类号： B01J20/32 ,  G01N30/00 ,  C07D251/50 ,  C07D251/48

CPC分类号： B01J20/289 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3244 ,  B01J20/3251 ,  B01J20/3253 ,  B01J20/3255 ,  B01J2220/54 ,  B01J2220/58 ,  C07D251/48 ,  C07D251/50 ,  C12Q1/56 ,  G01N33/86

摘要： For the separation, removal, isolation, purification, characterization, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or &bgr;-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and q is 2 to 6.