公开(公告)号：EP2865751A1

公开(公告)日：2015-04-29

申请号：EP14195875.1

申请日：2011-03-02

申请人： Protalix Ltd.

发明人： Shulman, Avidor ,  Ruderfer, Ilya ,  Ben-Moshe, Tehila ,  Shekhter, Talia ,  Azulay, Yaniv ,  Shaaltiel, Yoseph ,  Kizhner, Tali

IPC分类号： C12N9/40

CPC分类号： C12Y302/01022 ,  C12N9/2465

摘要： Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well as a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed mulitmeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.

摘要翻译： 本文公开了包含通过连接部分彼此共价连接的至少两个α-半乳糖苷酶单体的多聚体蛋白质结构，以及其制备方法，以及通过施用多聚体蛋白质结构治疗法布里病的方法。 根据在溶酶体条件和血清环境中增强的活性和/或更持久的活性方面，所公开的多药蛋白质结构表现出改进的性能。