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56 条记录 (耗时 0.033 秒)

    Stabilized alpha-galactosidase and uses thereof
    5.
    发明公开
    Stabilized alpha-galactosidase and uses thereof 有权
    Stabilisierte Alpha-Galaktosidase和Verwendungen davon

    公开(公告)号：EP2865751A1

    公开(公告)日：2015-04-29

    申请号：EP14195875.1

    申请日：2011-03-02

    申请人： Protalix Ltd.

    发明人： Shulman, Avidor ,  Ruderfer, Ilya ,  Ben-Moshe, Tehila ,  Shekhter, Talia ,  Azulay, Yaniv ,  Shaaltiel, Yoseph ,  Kizhner, Tali

    IPC分类号： C12N9/40

    CPC分类号： C12Y302/01022 ,  C12N9/2465

    摘要： Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well as a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed mulitmeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.

    摘要翻译： 本文公开了包含通过连接部分彼此共价连接的至少两个α-半乳糖苷酶单体的多聚体蛋白质结构，以及其制备方法，以及通过施用多聚体蛋白质结构治疗法布里病的方法。 根据在溶酶体条件和血清环境中增强的活性和/或更持久的活性方面，所公开的多药蛋白质结构表现出改进的性能。

    Mucosal or enteral administration of biologically active macromolecules
    7.
    发明公开
    Mucosal or enteral administration of biologically active macromolecules 审中-公开
    生物活性大分子的粘膜或肠内给药

    公开(公告)号：EP2484768A2

    公开(公告)日：2012-08-08

    申请号：EP11175328.1

    申请日：2006-07-18

    申请人： Protalix Ltd.

    发明人： Shaaltiel, Yoseph ,  Almon, Einat

    IPC分类号： C12N15/82

    CPC分类号： C12N15/8257 ,  C12N15/8258

    摘要： A unit dosage form for delivery of a biologically active recombinant biomolecule to a tissue of a subject, the unit dosage form comprising, a therapeutically effective amount of isolated plant cells of a plant cell culture, said isolated plant cells expressing the recombinant biomolecule.

    摘要翻译： 用于将生物活性重组生物分子递送至受试者组织的单位剂型，所述单位剂型包含治疗有效量的植物细胞培养物的分离的植物细胞，所述分离的植物细胞表达重组生物分子。

    SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF
    9.
    发明公开
    SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF 有权
    SACCHARID-HALTIGE蛋白质结核病在IHRE VERWENDUNGEN

    公开(公告)号：EP2192924A2

    公开(公告)日：2010-06-09

    申请号：EP08789815.1

    申请日：2008-08-20

    申请人： Protalix Ltd.

    发明人： SHULMAN, Avidor ,  RUDERFER, Ilya

    IPC分类号： A61K47/48 ,  A61P43/00

    CPC分类号： A61K47/48092 ,  A61K47/54 ,  A61K47/549

    摘要： Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.

    摘要翻译： 公开了通过非疏水性接头及其制备方法共价连接的糖和生物分子的缀合物。 还公开了利用这种缀合物的医学用途。 还公开了用于制备这些缀合物的糖基化试剂。 还公开了以改进的性能为特征的糖基化蛋白质。